癫痫患者运动锻炼效果的Meta分析

Effects of exercise on patients with epilepsy:a Meta-analysis

目的:通过Meta分析评价癫痫患者参与运动锻炼的干预效果,为临床实践提供循证依据。方法:系统检索PubMed、Embase、Cochrane Library、Web of Science、中国生物医学文献数据库、中国知网、万方和维普数据库中关于癫痫患者参与运动锻炼的随机对照试验,检索时限为建库至2023年9月29日,采用RevMan 5.4软件进行Meta分析。结果:纳入9篇文献,共400例患者。Meta分析结果显示,运动锻炼可降低患者癫痫发作频率[MD=-2.35,95%CI(-3.16,-1.54),P<0.001],未增加不良事件发生[RR=2.54,95%CI(0.11,56.25),P=0.56],可提高患者每日活动量[MD=1.39,95%CI(0.48,2.29),P=0.003],改善患者抑郁症状[SMD=0.90,95%CI(0.22,1.58),P=0.01]、认知功能[SMD=0.69,95%CI(0.03,1.35),P=0.04]和生活质量[SMD=0.43,95%CI(0.22,0.64),P<0.001]。但在改善焦虑症状[SMD=-1.27,95%CI(-3.00,0.46),P=0.15]方面,差异没有统计学意义。结论:癫痫患者执行科学制定的运动锻炼方案具有安全性,且可以有效改善患者抑郁症状、认知功能和生活质量,但对于改善患者焦虑症状效果不显著。

Objective:To conduct a Meta-analysis assessing the intervention effects of exercise participation in patients with epilepsy,aiming to provide evidence-based guidance for clinical practice.Methods:We searched randomized controlled trials on epilepsy patients having exercise from PubMed,Embase,Cochrane Library,Web of Science databases,CNKI,Wanfang database,VIP and CBM from their inception to September 29,2023.Meta-analysis was performed by RevMan 5.4.Results:A total of 9 studies involving 400 patients were finally included.The results showed that exercise reduced seizure frequency[MD=-2.35,95%CI(-3.16,-1.54),P<0.001],without an increased occurrence of adverse events[RR=2.54,95%CI(0.11,56.25),P=0.56].Furthermore,it could enhance the daily activity levels of patients[MD=1.39,95%CI(0.48,2.29),P=0.003],ameliorate depressive symptoms[SMD=0.90,95%CI(0.22,1.58),P=0.01],improve cognitive function[SMD=0.69,95%CI(0.03,1.35),P=0.04],and elevate the quality of life[SMD=0.43,95%CI(0.22,0.64),P<0.001].However,there was no statistically significant difference in improving anxiety symptoms[SMD=-1.27,95%CI(-3.00,0.46),P=0.15].Conclusion:The implementation of a scientifically developed exercise in patients with epilepsy was safe and effective in relieving depressive symptoms,improving cognitive function and life quality,but was not that obvious in reducing their anxiety symptoms.