血栓弹力图对鉴别重度子痫前期和HELLP综合征的临床应用价值研究

The clinical application value of thromboelastography in distinguishing severe preeclampsia from HELLP syndrome

目的探讨血栓弹力图(TEG)在重度子痫前期(sPE)和并发HELLP综合征中的应用价值。方法选取83例重度子痫前期孕妇为对照组,15例并发HELLP综合征孕妇为研究组。观察两组临床资料。结果研究组总胆红素(TBIL)、谷草转氨酶(AST)、肌酐(Cr)、乳酸脱氢酶(LDH)指标均高于对照组,血小板计数(PLT)指标低于对照组(P<0.05)。两组凝血指标比较,差异无统计学意义(P>0.05)。研究组最大血块强度(MA值)(64.56±5.28)mm低于对照组的(68.09±6.55)mm(P<0.05)。结论与传统凝血常规(CCTs)相比,TEG的MA值在sPE和HELLP综合征中有显著差异,可用于HELLP综合征的早期识别。

Objective To investigate the application value of thromboelastography(TEG)in severe preeclampsia(sPE)and HELLP syndrome.Methods 83 pregnant women with severe preeclampsia were selected as the control group and 15 pregnant women with HELLP syndrome were selected as the study group.The clinical data of the two groups were observed.Results The total bilirubin(TBIL),aspartate aminotransferase(AST),creatinine(Cr)and lactate dehydrogenase(LDH)indexes of the study group were higher than those of the control group,and the platelet count(PLT)indexes were lower than those of the control group(P<0.05).There was no significant difference in coagulation indexes between the two groups(P>0.05).The maximum clot intensity(MA value)in the study group was(64.56±5.28)mm,lower than(68.09±6.55)mm in the control group(P<0.05).Conclusion Compared with conventional coagulation tests(CCTs),the MA value of TEG is significantly different in sPE and HELLP syndrome,and can be used for early identification of HELLP syndrome.