产后抑郁障碍患者认知功能与细胞因子相关性研究

The correlation between cognitive function and cytokines levels in patients with postpartum depression

目的研究产后抑郁障碍(PPD)患者的认知功能损害与细胞因子水平的相关性。方法选取56例PPD患者作为PPD组,另选取同期44例健康产妇作为对照组。两组均进行认知功能缺陷自评量表(PDQ-D)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分,并检测血清细胞因子水平,分析细胞因子与认知功能、情绪的相关性。结果PPD组HAMA、HAMD、PDQ-D评分均高于对照组(P<0.05)。PPD组的白介素-6(IL-6)水平(2.99±1.93)pg/ml显著高于对照组的(1.93±0.94)pg/ml(P<0.05)。对认知功能、情绪与细胞因子进行相关性检验,各指标间无相关性(P>0.05)。结论PPD患者存在免疫炎性反应,同时存在认知功能障碍及不良情绪,免疫炎性指标可能在PPD患者认知功能及情绪障碍中发挥作用,但仍需进一步深入研究。

Objective To investigate the relationship between cognitive impairment and cytokine levels in patients with postpartum depression disorder(PPD).Methods 56 patients with PPD were selected as PPD group,and 44 healthy parturients were selected as control group.The Perceived Deficit Questionnaire for Depression(PDQ-D),hamilton depression scale(HAMD)and hamilton anxiety scale(HAMA)scores were performed in both groups,and serum cytokine levels were detected to analyze the correlation between cytokines and cognitive function and emotion.Results The HAMA,HAMD and PDQ-D scores in PPD group were high than those in control group(P<0.05).The level of interleukin-6(IL-6)in PPD group(2.99±1.93)pg/ml was significantly higher than that in control group(1.93±0.94)pg/ml(P<0.05).There was no correlation between cognitive function,emotion and cytokines(P>0.05).Conclusion PPD patients have immunoinflammatory response,cognitive dysfunction and adverse mood,and immunoinflammatory indicators may play a role in cognitive function and mood disorders in PPD patients,but further research is needed.