注射用还原型谷胱甘肽对酒精性肝病患者的肝功能及肝纤维化指标的影响

Effects of Reduced Glutathione for Injection on liver function and liver fibrosis indexes in patients with alcoholic liver disease

目的 观察注射用还原型谷胱甘肽对酒精性肝病的疗效及对肝功能、肝纤维化指标的影响。方法 选取2020年10月至2022年10月淮南东方医院集团总院收治的酒精性肝病患者80例,按照随机数字表法将其分为对照组和观察组,各40例。对照组静脉滴注异甘草酸镁注射液、门冬氨酸钾镁注射液,观察组在对照组基础上增加注射用还原型谷胱甘肽。两组均治疗2周。比较两组临床疗效;比较两组治疗前后肝功能[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBil)]及肝纤维化指标[透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原肽(PⅢP)];记录两组不良反应发生情况。结果 观察组临床疗效优于对照组(P<0.05)。治疗后,两组ALT、AST、TBil水平低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组HA、LN、PⅢP水平低于治疗前,且观察组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 注射用还原型谷胱甘肽对于酒精性肝病患者疗效确切,有利于改善肝功能、抑制肝纤维化,且安全性较高,值得进一步研究推广。

Objective To observe the effect of Reduced Glutathione for Injection on alcoholic liver disease,liver function,and liver fibrosis.Methods A total of 80 patients with alcoholic liver disease admitted to Huainan Oriental Hospital Group General Hospital from October 2020 to October 2022 were selected.They were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was given intravenously Magnesium Isoglycyrrhizinate Injection and Potassium Aspartate and Magnesium Aspartate Injection,observation group was supplemented with Reduced Glutathione for Injection on the basis of control group.Both groups were treated for two weeks.The clinical effect of two groups was compared;liver function(alanine aminotransferase [ALT],aspartate transaminase[AST],and total bilirubin [TBil]) and liver fibrosis indexes(hyaluronic acid [HA],laminin [LN],and type Ⅲ procollagen peptide [PⅢP]) were compared between two groups before and after treatment;and the occurrence of adverse reactions in two groups was recorded.Results The clinical effect of observation group was better than that of control group(P<0.05).After treatment,the levels of ALT,AST,and TBil in two groups were lower than those before treatment,and observation group was lower than control group(P<0.05).After treatment,the levels of HA,LN,and PⅢP in two groups were lower than those before treatment,and observation group was lower than control group(P <0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion Reduced Glutathione for Injection has a definite effect on alcoholic liver disease patients,is beneficial to improve liver function,inhibit liver fibrosis,and is safe,worthy of further research and promotion.