盐酸多奈哌齐联合孙氏经颅重复针刺法治疗阿尔茨海默病的效果

Effects of Donepezil Hydrochloride combined with Sun's repeated transcranial acupuncture in the treatment of Alzheimer's disease

目的 观察盐酸多奈哌齐联合孙氏经颅重复针刺法治疗阿尔茨海默病(AD)的临床效果。方法 选取2022年9月至2023年9月黑龙江中医药大学附属第二医院哈南分院针灸门诊收治的90例AD患者,按照随机数字表法将其分为观察组、对照A组、对照B组,各30例。对照A组给予口服盐酸多奈哌齐治疗,对照B组行孙氏经颅重复针刺法治疗,观察组为盐酸多奈哌齐联合孙氏经颅重复针刺法治疗,均治疗8周。评价其临床疗效。比较三组治疗前及治疗后4、8周简易智力状态检查量表(MMSE)、阿尔茨海默病认知评估量表(ADAS-cog)和日常生活活动能力量表(ADL)评分及血清同型半胱氨酸(Hcy)水平。结果 观察组临床疗效优于对照A组及对照B组,差异有统计学意义(P<0.05)。三组治疗后4、8周MMSE评分高于治疗前,ADAS-cog、ADL评分和血清Hcy水平低于治疗前,差异有统计学意义(P<0.05);三组治疗后8周MMSE评分高于治疗后4周,ADAS-cog、ADL评分和血清Hcy水平低于治疗后4周,差异有统计学意义(P<0.05)。治疗后8周,观察组MMSE评分高于对照A组和对照B组,ADAS-cog、ADL评分和血清Hcy水平低于对照A组和对照B组,差异有统计学意义(P<0.05)。结论盐酸多奈哌齐联合孙氏经颅重复针刺法可改善轻中度AD患者的认知功能及行为能力,降低血清Hcy水平,且效果优于单纯口服多奈哌齐和孙氏经颅重复针刺法,值得临床推广。

Objective To observe the clinical efficacy of Donepezil Hydrochloride combined with Sun's repeated transcranial acupuncture in the treatment of Alzheimer's disease(AD).Methods From September 2022 to September 2023,90 AD patients who were admitted to the Acupuncture and Moxibustion Clinic,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Hanan Branch Hospital were divided into observation group,control group A,and control group B by random number table method,with 30 cases in each group.Control group A was treated with oral administration of Donepezil Hydrochloride,control group B was treated with Sun's repeated transcranial acupuncture,and observation group was treated with Donepezil Hydrochloride combined with Sun's repeated transcranial acupuncture,treated for eight weeks.Tts clinical effect was evaluated.The scores of the mini mental state examination(MMSE),Alzheimer's disease assessment scale cognitive subscale(ADAS-cog),and activities of daily living(ADL),as well as serum homocysteine(Hcy) levels before treatment and after four and eight weeks of treatment among three groups were compared.Results The clinical efficacy of the observation group was better than that of control group A and control group B,and the differences were statistically significant(P<0.05).At 4 and 8 weeks after treatment,MMSE scores in three group were higher than before treatment,ADAS-cog,ADL scores and serum Hcy levels were lower than before treatment,the differences were statistically significant(P<0.05).The MMSE scores at 8 weeks after treatment were higher than those at4 weeks after treatment,and the scores of ADAS-cog,ADL and serum Hcy levels were lower than those at 4 weeks after treatment,with statistical significances(P<0.05).At 8 weeks after treatment,MMSE scores in observation group were higher than those in control group A and control group B,ADAS-cog,ADL scores and serum Hcy levels were lower than those in control group A and control group B,and the differences were statistically significant(P<0.05).Conclusion Donepezil Hydrochloride combined with Sun's repeated transcranial acupuncture can improve the cognitive function and behavioral ability of patients with mild to moderate AD,and reduce the level of serum Hcy,and the effect is better than oral Donepezil and Sun's repeated transcranial acupuncture,which is worthy of clinical promotion.