川芎挥发油化学成分、制剂及药理作用研究进展

Research Progress of Chemical Constituents,Preparations and Pharmacological Effect of Essential Oil of Chuanxiong(Chuanxiong Rhizoma)

川芎是我国常用传统中药,其中挥发油是主要药效成分,一直是川芎研究工作的重点。早期对川芎挥发性成分的研究主要集中在其中化学成分的定性鉴定及定量分析。近年来研究者对川芎挥发油的研究逐渐深入,开展了川芎不同部位挥发油的差异分析,比较了加工制备方法对挥发油成分的影响;研究人员除了对川芎挥发油镇痛镇静、保护神经细胞、改善血管功能等药理作用及其机制进行深入研究外,新的研究发现川芎挥发油还具有骨保护、抗肿瘤、抗抑郁等药理活性。该文对近年来围绕川芎挥发油性成分的最新研究进展进行汇总,总结不同部位、不同产地、不同加工提取方法挥发油成分种类和含量差异,并综述了川芎挥发油制剂及药理活性研究进展,以期为更好地开发利用川芎挥发油自然资源提供参考。

Chuanxiong(Chuanxiong Rhizoma)is a commonly used traditional Chinese medicine,in which volatile oil is the main component,and has been the focus of research.Early studies on the volatile components of Chuanxiong(Chuanxiong Rhizoma)were mainly focused on the qualitative identification and quantitative analysis of the chemical components.In recent years,researchers have been studying the volatile oil of Chuanxiong(Chuanxiong Rhizoma)in depth,analysing the differences in the volatile oil of different parts of the plant andcomparing the effects of processing and preparation methods on the composition of the volatile oil;In addition to indepth studies on the pharmacological effects of Chuanxiong volatile oil such as analgesia and sedation,protection of nerve cells and improvement of vascular function and their mechanisms,new studies have found that Chuanxiong volatile oil also has pharmacological activities such as osteoprotective effects,antitumor and antidepressant.This paper summarizes the latest research progress on the volatile oil components of Chuanxiong(Chuanxiong Rhizoma),summarizes the differences in the types and contents of volatile oil components between different parts,different origins and different processing and extraction methods,and reviews the research progress on the preparations and pharmacological activities of the volatile oil of Chuanxiong(Chuanxiong Rhizoma),with a view to providing reference for the better exploitation of the natural resources of Chuanxiong(Chuanxiong Rhizoma).