“肺虚络瘀”病机观与氧化应激在慢性阻塞性肺疾病发病过程中相关性探讨

Discussion on the Correlation between the Pathogenesis of Lung Deficiency and Collateral Stasis and Oxidative Stress in COPD

将“肺虚络瘀”病机观为作为慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)发病的核心理论指导以探讨其与氧化应激的相关性,结合对COPD机制的现代临床调查与实验研究,对COPD病理改变过程中出现的氧化应激进行分析与探讨,认为氧化应激是COPD的重要病机之一;从肺虚对机体氧化-抗氧化平衡调节失调,提出COPD氧化-抗氧化失衡是肺虚的微观病理表现基础;氧化应激及其产生的病理改变与“肺虚络瘀”具有相同的病机改变表现;通补肺络法通过调节机体的氧化-抗氧化水平,减轻氧化应激,延缓COPD进程,从这3个方面深入探究COPD的“肺虚络瘀”病机制论与氧化应激的相关性,全面阐释COPD“肺虚络瘀”病机观的科学内涵,并从分子机制水平上诠释从肺络论治COPD的作用机制与靶点,为COPD的中医药治疗与其治疗机制研究提供新的思路及科学依据。

The pathogenesis of“lung deficiency and collateral stasis”as the core theory of chronic obstructive pulmonary disease(COPD)to guide the discussion of its correlation with oxidative stress,combined with the mechanism of COPD modern clinical research and experimental research,the oxidative stress in the process of pathological change of COPD were analyzed and discussed,it is considered that oxidative stress is one of the important pathogenesis of COPD.Based on the imbalance of oxygen-antioxidant balance caused by lung deficiency,it is suggested that oxygen-antioxidant imbalance in COPD is the basis of microscopic pathological manifestations of lung deficiency.Oxidative stress and its pathological changes have the same pathogenesis as“lung deficiency and collateral stasis”.By regulating the oxygen-antioxidant level of the body,the method of tonifying lung and collateralizing arteries can alleviate oxidative stress and delay the process of COPD.From these three aspects,the correlation between the pathogenesis theory of“lung deficiency and collateral stasis”of COPD and oxidative stress is deeply explored,and the scientific connotation of the pathogenesis theory of“lung deficiency and collateral stasis”of COPD is comprehensively explained.In addition,the mechanism and target of treating COPD based on pulmonary collaterals are interpreted from the molecular mechanism level,providing new ideas and scientific basis for the study of TCM treatment of COPD and its treatment mechanism.