半夏化学成分、药理作用研究进展及其质量标志物预测分析

Research Progress on Chemical Constituents and Pharmacological Effects of Banxia(Pinelliae Rhizoma)and Prediction Analysis of Quality Markers

半夏始载于《神农本草经》,味多辛苦,性多温燥,有毒,主归脾、胃、肺经,是我国常见的大宗药材,具有燥湿化痰、降逆止呕、消痞散结之功,常配伍于中药方剂作为君药使用。半夏来源广泛,成分丰富,药效显著,在我国临床治疗史上具有广阔前景。该文以质量标志物(Q-Marker)理论为指导,结合国内外文献报道,归纳总结了半夏化学成分和药理作用,从亲缘关系、传统药性、化学成分有效性、成分可测性和不同配伍环境等方面对半夏进行Q-Marker的预测分析,以期为半夏建立更科学、更合理的质量评价体系,为其进一步综合利用提供参考。

Banxia(Pinelliae Rhizoma)began in the ShennongMateriaMedica,taste more laborious,more warm dry,toxic,the main return to the spleen,stomach,lung meridian,is a common bulk medicinal materials,with dryness and dampness phlegm,reduce reverse vomiting,eliminate ruffisanjie work,often mixed with the traditional Chinese medicine as a king.Banxia(Pinelliae Rhizoma)has a wide range of sources,rich ingredients,significant pharmacological effects and broad application prospects in the development of clinical treatment history.In this paper,guided by the Q-Marker theory and combined with domestic and foreign literature reports,the chemical constituents and pharmacological effects of Banxia(Pinelliae Rhizoma)were summarized,and Q-Marker was used to predict and analyze Banxia(Pinelliae Rhizoma)from the aspects of kinship,traditional medicine,efficacy,component measuability and different compatible environments.In order to establish a more scientific and reasonable quality evaluation system for Banxia(Pinelliae Rhizoma),and provide reference for its further comprehensive utilization.