肠道菌群调节治疗慢性阻塞性肺疾病的研究进展

Research progress on regulating gut microbiome to treat chronic obstructive pulmonary disease

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是一种临床常见的慢性气道疾病。虽然现有的治疗策略能有效控制和缓解疾病症状,但COPD病程迁延难愈,需要新的治疗方案以阻止疾病进展、逆转肺功能恶化。随着近年对肺肠轴的研究不断深入,通过干预肠道菌群防治COPD的研究也在逐步推进。该文对肠道菌群调节治疗COPD的研究进展作一综述,旨在探索COPD防治的新思路,为后续以肺肠轴为核心的治疗策略的临床研究与应用提供方向。

Chronic obstructive pulmonary disease(COPD) is a common clinical chronic airway disease.Although the existing treatment strategies can effectively control and relieve the symptoms of the disease,the disease is difficult to recover.New approaches are required to prevent the progress of the disease and reverse lung function deterioration.With the development of the gut-lung axis research in recent years,the study of prevention and treatment of COPD through intervention of the gut microbiome is gradually advancing.This article reviewed the research progress on regulating gut microbiome to treat COPD,aiming to explore new ideas for COPD prevention and provide direction for further clinical research and application of therapies based on the lung-gut axis.