多组学在阿霉素心脏毒性中的研究进展

Research progress of multiomics in Doxorubicin-induced cardiotoxicity

阿霉素心脏毒性(DIC)是限制阿霉素(DOX)临床应用的重要因素。目前DIC的机制尚不明确且无有效预防手段。因此亟需从DNA、RNA、蛋白质和代谢产物等方面探究DIC的发生发展机制,以寻找新的方法对DIC进行诊断与防治。随着高通量技术的兴起与发展,基因组学、转录组学、蛋白质组学和代谢组学等方法在探索DIC潜在的生物标志物、代谢通路及发病机制上取得了巨大的进步。本文综述了多组学技术在DIC研究中取得的最新成果和进展,为进一步阐明DIC发病机制提供新的思路。

Doxorubicin-induced cardiotoxicity(DIC)is an important factor limiting the clinical use of Doxorubicin(DOX).At present,the mechanism of DIC is not clear.There are also no effective preventive measures.Therefore,it is urgent to explore the occurrence and development of DIC from the aspects of DNA,RNA,protein,and metabolites,so as to find a new way to diagnose and prevent DIC.With the rise and development of high-throughput technologies,genomics,transcriptomics,proteomics,and metabolomics have made great progress in exploring potential biomarkers,metabolic pathways,and pathogenesis of DIC.This paper reviews the latest achievements and progress of multi-omics technology in the study of DIC,which provides a new idea for further elucidating the pathogenesis of DIC.