肠道微生物疗法干预孤独症谱系障碍的研究进展

Research progress of intestinal microbiotherapy on intervention autism spectrum disorder

孤独症谱系障碍(ASD)是一种复杂的神经发育疾病,发病率逐年上升。除了语言、行为和社交受损症状外,大部分患儿伴有不同程度的胃肠道症状。目前,ASD病理机制不明,随着对肠道菌群的深入研究,发现ASD患儿的症状与肠道微生物密切相关。因此,调节肠道菌群成为防治ASD的热点之一。本文就肠道微生态对ASD的影响,通过肠道微生物(益生菌、益生元、粪便微生物移植)干预对“脑肠轴”的机制和作用进行综述,旨在为ASD的发病机制和临床治疗提供新理论基础、新思路。

Autism spectrum disorder(ASD) is a complex neurodevelopmental disorder and the prevalence has been increasing.In addition to symptoms of impaired communication,behaviors,and social interaction,most of children patients are accompanied by different degrees of gastrointestinal symptoms.At present,the pathological mechanism of ASD is still unclear,with the in-depth study of intestinal microflora,it has been found that symptoms in children patients with ASD are closely related to intestinal microbiota.Therefore,regulation of intestinal microflora have become one of the hot spots in prevention and treatment of ASD.Based on the impact of intestinal microflora on ASD,this paper reviews the mechanism and effect of “brain-gut axis”through intestinal microbial(probiotics,prebiotics,and fecal microbiota transplantation)intervention on ASD,aiming to provide new theoretical basis and new ideas for the pathogenesis and clinical treatment of ASD.