基于数据挖掘分析朱彩凤治疗肾风用药规律

Study on the Medication Rules of ZHU Caifeng in Treating Kidney-Wind Edema Based on Data Mining

目的:分析朱彩凤教授中医药治疗肾风(IgA肾病)的用药规律和临床经验。方法:收集整理朱彩凤教授治疗肾穿刺活检后的首诊IgA肾病患者病例,并将规范的病例信息输入数据库。选取符合标准的336张处方,统计其中药功效、性味归经等,根据患者是否服用糖皮质激素分成A组和B组,在SPSS Modeler 18.0和SPSS Statistics 25、中医药传承平台3.0等软件中进行中药用药频次统计、中医证型、关联规则、复杂系统熵聚类方法的数据挖掘。结果:在336张处方中,A、B两组分别统计出30余种高频药物,分别提取出5个核心处方。朱彩凤教授治疗肾风(IgA肾病)用药极简,补虚治疗为基石、重视宣上清下,对于是否服用糖皮质激素的患者分而治之,未使用激素患者多加用祛风湿类中药,病久多加用活血化瘀之品,并重视顾护胃气,兼用固涩塞流。结论:对IgA肾病患者处方进行数据挖掘,可以总结出朱彩凤教授治疗IgA肾病的用药规律和临床经验,有利于更好地继承朱彩凤教授的学术经验。

Objective:To analysis the medication rules and clinical experience of Professor ZHU Caifeng's treatment of kidney-wind edema(IgA nephropathy) with traditional Chinese medicine(TCM).Methods:The cases of patients with IgA nephropathy who were first diagnosed that treated by Professor ZHU Caifeng after renal biopsy were collected and the standardized case information was input into the database.A total of 336 prescriptions that met the standard were selected,and the efficacy of traditional Chinese medicine,four properties and five flavors and meridian tropism were counted.Patients were divided into two groups,A and B,according to whether they took glucocorticoids.SPSS Modeler 18.0,SPSS Statistics 25,TCM inheritance Platform 3.0 and other softwares were used for data mining of TCM drug frequency statistics,TCM syndrome types,association rules,and complex system entropy clustering methods.Results:Among 336 prescriptions,more than 30 kinds of high-frequency drugs were counted in group A and group B,and 5 core prescriptions were extracted respectively.Professor ZHU Caifeng treated kidney-wind edema(IgA nephropathy) with minimal medication,supplementing deficiency treatment as the cornerstone,pay attention to disffuse the upper jiao and clear the lower jiao.Divide and conquer patients who take glucocorticoids or not,patients who do not use hormones should use more Chinese medicine for removing wind and dampness,patients who have been ill for a long time should use more products to promote blood circulation and remove blood stasis,pay attention to the protection of stomach qi,and consolidating essence and blocking the drainage at the same time.Conclusion:The prescription data mining for patients with IgA nephropathy can summarize the medication rules and clinical experience of Professor ZHU Caifeng in the treatment of IgA nephropathy,which is conducive to our better inheritance of Professor ZHU Caifeng's academic experience.