DVS技术在药物晶型和共晶研究中的应用进展

Application Progress of DVS in the Studies of Drug Polymorphism and Cocrystals

动态蒸汽吸附(DVS)技术是药物晶型和共晶研究的重要工具。DVS技术不仅可用于评价药物的吸湿性能,还可以用于研究相变问题、共晶筛选、定量分析晶体中低水平的无定型物含量以及其他方面的应用。目前,DVS技术已被多个国家或地区的药典收录,用于水分-固体相互作用的研究。我国药典尚未收载DVS技术,有待完善。该文主要概述了DVS技术在药物晶型和共晶研究中的应用及进展,旨在为晶型药物的相关研究提供一定参考。

Dynamic vapor sorption(DVS)technology is served as a crucial tool for the examination of pharmaceutical crystal forms and co-crystals.Not only can DVS technology assess moisture sorption performance of an API,but it also probes into phase transition issues,co-crystal screening,quantification of amorphous content at low levels in crystalline materials,as well as the miscellaneous.At present,many countries and regions have included DVS technology into their pharmacopoeias for the exploration of water-solid interactions.However,the Chinese pharmacopoeia has not recorded this technology.This paper provides an overview of the application and advance of DVS technology in the investigation of pharmaceutical crystal forms and co-crystals,as a reference for related research on polymorphism of drugs.