针对性干预对子宫内膜癌患者术后炎性反应及恢复进程的影响

Effect of targeted intervention on postoperative inflammatory response and recovery process in patients with endometrial cancer

目的探讨针对性干预对子宫内膜癌患者术后炎性反应与恢复进程的影响。方法将106例子宫内膜癌患者按干预方法的不同分为常规组及针对组,每组53例。常规组患者给予常规围手术期干预,针对组患者给予针对性干预。比较两组患者的临床指标、血清炎性反应指标[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、氧化应激指标[晚期氧化蛋白产物(AOPP)、活性氧(ROS)、丙二醛(MDA)]、血清创伤标志物[总抗氧化能力(TAC)、肌红蛋白(MYO)、缺血修饰清蛋白(IMA)],出院前统计两组患者术后并发症发生情况。结果针对组患者术后排气时间、开始床旁活动时间、置管时间、住院时间均明显短于常规组,差异均有统计学意义(P﹤0.01)。术后,两组患者血清CRP、TNF-α、IL-6水平均高于本组术前,但针对组患者CRP、TNF-α、IL-6水平均低于常规组,差异均有统计学意义(P﹤0.05)。术后,两组患者血清TAC水平均低于本组术前,MYO、IMA水平均高于本组术前,但针对组患者TAC水平高于常规组,MYO、IMA水平均低于常规组,差异均有统计学意义(P﹤0.05)。术后,两组患者血清AOPP、ROS、MDA水平均高于本组术前,但针对组患者AOPP、ROS、MDA水平均低于常规组,差异均有统计学意义(P﹤0.05)。针对组患者并发症总发生率低于常规组,差异有统计学意义(P﹤0.05)。结论针对性干预可减轻子宫内膜癌患者术后炎性反应与氧化应激反应程度,改善血清创伤标志物水平,缩短患者术后恢复进程,辅助提高手术安全性。

Objective To investigate the effect of targeted intervention on postoperative inflammatory response and recovery process in patients with endometrial cancer.Method A total of 106 patients with endometrial cancer were divided into conventional group and target group according to different intervention methods,with 53 cases in each group.Patients in the conventional group were given routine perioperative intervention,and patients in the target group were given targeted intervention.Clinical indicators,serum inflammatory response indicators[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],oxidative stress indicators[advanced oxidized protein product(AOPP),reactive oxygen species(ROS),malondialdehyde(MDA)],serum trauma markers[total antioxidant capacity(TAC),myoglobin(MYO),ischaemic modified albumin(IMA)]were compared between the two groups.The incidence of postoperative complications in the two groups were analyzed before discharge.Result The postoperative exhaust time,start bedside activity time,catheterization time and hospital stay in the target group were significantly shorter than those in the conventional group,the differences were statistically significant(P<0.01).After surgery,the serum levels of CRP,TNF-αand IL-6 in two groups were higher than those before surgery,but the levels of CRP,TNF-αand IL-6 in target group were lower than those in conventional group,the differences were statistically significant(P<0.05).After surgery,serum TAC levels in two groups were lower than those before surgery,MYO and IMA levels were higher than those before surgery,but TAC level in target group was higher than that in conventional group,MYO and IMA levels were lower than those in conventional group,the differences were statistically significant(P<0.05).After surgery,serum AOPP,ROS and MDA levels in the two groups were higher than those before surgery,but AOPP,ROS and MDA levels in target groups were lower than those in conventional group,the differences were statistically significant(P<0.05).The total incidence of complications in targeted group was lower than that in conventional group,and the difference was statistically significant(P<0.05).Conclusion Targeted intervention can reduce the inflammatory response and oxidative stress response of patients with endometrial cancer,improve the levels of serum trauma markers,shorten the postoperative recovery process,and help improve the safety of surgery.