药物联合物理治疗根除HP^+消化性溃疡再出血的临床研究

Clincal Study on the Use of Combination of Takepron and Minimeter Wave to Eradicate Peptic Ulcer with Helicobacter Pylori and to Prevent Rehemorrhage

目的 :探讨药物 (达克普隆 )联合毫米波 (mmW)对根除HP阳性的消化性溃疡再出血的疗效。方法 :对消化性溃疡并出血的病人 ,随机选择HP阳性的病人分A组 (治疗组 )、B组 (对照组 )、HP阴性组 (C组 ) ,均用达克普隆治疗 ,30mg/次 ,2次 /d ,共 2周 ,A组加用毫米波治疗。治疗 32周后 ,均再服用达克普隆 ,1次 /d ,共 2周。随访 18个月。结果 :ABC三组患者溃疡愈合率分别为 10 0 % ,94 .8% ,95 % ,三组互相比较无明显差异 (P >0 .0 5 ) ,A ,B两组Hp根除率为 87.1%和 15 .3% ,两者相比有显著差异 (P <0 .0 5 ) ,随访 18个月后 ,两组再出血率分别为 2 .5 6 %和 30 .7% ,两者相比有显著差异 (P <0 .0 5 )。而C组再出血率为 12 .5 % ,与AB两组比较无显著差异 (P >0 .0 5 )。结论 :达克普隆联合毫米波治疗对溃疡愈合与HP根除优于单用达克普隆治疗 。

Objective:To study therapeutic effects of the combination of takepron and minimeter Wave(mmW)on eradication of peptic ulcer with helicobacter pylori(HP)and prevention of rehemorrhage. Methods:Cases with peptic ulcer(pu)complicated by hemorrhage were administrated emergency gastroscope. HP was examined from gastric antrum tissue;Cases of the HP were randomly divided into group A daily for 2 weeks and group B (the control group,treated with takepron 30 mg, twice daily for 2 weeks).Cases of group C without HP were treated with takepron 30 mg, twice daily for 2 weeks.Three groups received emergency gastroscope and examination of HP after the course of treatment;they were followed up for 18 months. Results:After treatment, the healing rates of pu of Groups A,B,and C were 100%?94.5%,and 95%( P > 0.05 ),respectively.The eradicated rates of HP of Groups A and B were 87.1% and 15.3%( P < 0.05 ),respectively. After followed up for 18 months,the rehemorrhangic rates of Group A and B were 2.56% and 30.7%( P < 0.05 ),respectively.The rehmorrhagic rate of Group C was 12.5%,compared to A and B group, the rehemorrhagic rate was not significantly different ( P >0.05).Conclusion:Healing of pu and eradication of HP with the combination of mmW and takepron are prevalent against takepron;rehemorrhagic rate is lower,so it is necessary that the cases of pu, with HP complicated by hemorrhage, are to receive the eradicated treatment of HP,which may prevent rehemorrhage of pu.