摘要
药理研究表明白芍具有抗炎、免疫调节、保肝、镇痛等作用,在临床上白芍及白芍总苷常用于治疗自身免疫性疾病。随着白芍及白芍总苷在抗炎和免疫调节中的作用机制逐步被认识,它们在免疫相关性、炎症性皮肤病中的临床应用得到了不断扩展,通过抗炎、免疫调节和抗氧化等机制在增效减毒、降低疾病复发率方面发挥重要作用。本文对白芍及白芍总苷治疗免疫相关性、炎症性皮肤病的作用及机制的研究进展进行综述,为其深入研究提供依据。
Pharmacological studies have shown that white paeony has anti-inflammatory,immunomodulatory,hepatoprotective,and analgesic effects.In clinical practice,paeony and total glucosides of paeony are often used to treat autoimmune diseases.As the anti-inflammatory,immune-modulating and anti-oxidizing mechanisms of paeony and total glucosides of paeony are gradually understood,their clinical applications in immune-related and inflammatory skin diseases have been continuously expanded.The mechanisms such as anti-oxidation play an important role in enhancing efficacy,attenuating toxicity,and reducing disease recurrence rates.This article reviews the research progresses on the effects and mechanisms of paeony and total glucosides of paeony in the treatment of immune-related and inflammatory skin diseases,to provide a basis for in-depth research.
作者
杨阳
陈睿轩
闵力
马致洁
梅雪岭
Yang Yang;Chen Ruixuan;Min Li;Ma Zhijie;Mei Xueling(Department of Education,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;School of Pharmacy,Shanxi Medical University,Taiyuan 030001,China;Department of Gastroenterology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Pharmacy,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Dermatology and Venereology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
出处
《首都医科大学学报》
CAS
北大核心
2024年第1期1-7,共7页
Journal of Capital Medical University
基金
首都卫生发展科研专项项目(首发2022-2-20212)。
关键词
白芍
白芍总苷
自身免疫性皮肤病
机制研究
paeony
total glucosides of paeony
autoimmune skin disease
mechanism study