白芍及白芍总苷治疗自身免疫性皮肤病的作用及机制研究进展

Research progress of effects and mechanisms of paeony and total glucosides of paeony in treatment of immune-associated dermatoses

药理研究表明白芍具有抗炎、免疫调节、保肝、镇痛等作用,在临床上白芍及白芍总苷常用于治疗自身免疫性疾病。随着白芍及白芍总苷在抗炎和免疫调节中的作用机制逐步被认识,它们在免疫相关性、炎症性皮肤病中的临床应用得到了不断扩展,通过抗炎、免疫调节和抗氧化等机制在增效减毒、降低疾病复发率方面发挥重要作用。本文对白芍及白芍总苷治疗免疫相关性、炎症性皮肤病的作用及机制的研究进展进行综述,为其深入研究提供依据。

Pharmacological studies have shown that white paeony has anti-inflammatory,immunomodulatory,hepatoprotective,and analgesic effects.In clinical practice,paeony and total glucosides of paeony are often used to treat autoimmune diseases.As the anti-inflammatory,immune-modulating and anti-oxidizing mechanisms of paeony and total glucosides of paeony are gradually understood,their clinical applications in immune-related and inflammatory skin diseases have been continuously expanded.The mechanisms such as anti-oxidation play an important role in enhancing efficacy,attenuating toxicity,and reducing disease recurrence rates.This article reviews the research progresses on the effects and mechanisms of paeony and total glucosides of paeony in the treatment of immune-related and inflammatory skin diseases,to provide a basis for in-depth research.