摘要
原发性醛固酮增多症(PA)是继发性高血压的常见原因,容易造成终末器官心脏和肾脏的损伤。因此,早期诊断和适当治疗对改善PA患者的预后至关重要。在PA的临床实践中,PA的侧化分析是必不可少的一步。肾上腺静脉取样虽然被指南推荐为临床诊断PA侧化病变的金标准,但其侵入性和技术难度的原因限制了该技术在地区医院的应用。相比之下,功能分子影像学这一非侵入性技术无创且操作简单,可以弥补肾上腺静脉取样在PA侧化分析中的不足,亦能有助于PA的治疗决策。本文介绍了功能分子影像学在PA中的国内外研究现状及发展动态,讨论了各种肾上腺功能分子成像技术的生理机制、优缺点和临床应用,并指出了未来肾上腺功能分子成像技术的突破和发展的方向,以期为PA的侧化分析和亚型诊断提供参考依据。
Primary aldosteronism(PA)is a common cause of secondary hypertension and prones to cause damage to the end-organs,such as heart and kidney.Consequently,early diagnosis and adequate treatment can improve the prognosis of PA patients.Lateralization analysis of PA is a crucial stage in clinical practice.While adrenal vein sampling is recommended by guidelines as the gold standard for lateralization analysis of PA,the technique's invasiveness and technical difficulty limit its widespread application in regional hospitals.However,functional molecular imaging,which is easy to use and non-invasive,can offset the shortcomings of adrenal vein sampling in PA lateralization analysis,and can also provide powerful support in treatment decisions for PA.In order to provide a reference basis for lateralization analysis and subtype diagnosis of PA,we described the current state and progression of functional molecular imaging in PA both domestically and internationally.The physiological mechanisms,benefits,drawbacks and clinical applications of various adrenal functional molecular imaging techniques were also addressed in detail.Finally,we proposed the potential breakthrough and development direction of adrenal functional molecular imaging technology in the future.
作者
黄笑
杨宜恒
唐江峰
田清山
杨鹏
HUANG Xiao;YANG Yiheng;TANG Jiangfeng;TIAN Qingshan;YANG Peng(Department of Cardiology,Jiangxi provincial People's Hospital,The First Affiliated Hospital of Nanchang Medical College,Nanchang 330006,China;Department of Cardiology,The First Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,China)
出处
《分子影像学杂志》
2024年第2期206-211,共6页
Journal of Molecular Imaging
基金
江西省卫生健康委普通科技计划(202210163)。