精神分裂症糖脂代谢紊乱与睡眠障碍关系的研究进展

Research progress on the relationship between glycolipid metabolism disorders and sleep disorders in schizophrenia

精神分裂症是一种严重的精神疾病,具有高发病率、高致残率及高病死率的特点。越来越多的研究发现,精神分裂症糖脂代谢紊乱与睡眠障碍相关,病理生理机制尚不明确。目前研究提出,睡眠障碍作为精神分裂症患者常见的临床症状,可能通过神经内分泌系统、肠道微生物等影响精神分裂症糖脂代谢紊乱的发生和发展。文章着重从失眠、中枢性嗜睡症、昼夜节律睡眠-觉醒障碍、阻塞性睡眠呼吸暂停四个方面对精神分裂症伴糖脂代谢紊乱的相关研究进展进行综述,为精神分裂症患者心血管疾病的防治提供思路。

Schizophrenia is a serious mental disease with high incidence,high disability rate and high mortality.A growing body of research has found that the glycolipid metabolism disorder in schizophrenia is related to sleep disorders,and the pathological and physiological mechanisms are not yet clear.At present,research suggests that sleep disorders,as a common clinical symptom in patients with schizophrenia,may affect the occurrence and development of glycolipid metabolism disorders in schizophrenia through the neuroendocrine system,intestinal microbiota,and other factors.The paper focuses on summarizing the research progress of schizophrenia with glycolipid metabolism disorders from four aspects,including insomnia,central disorder of hypersomnolence,circadian sleep-wake disorder,and obstructive sleep apnea,providing new recommendations for the prevention and treatment of cardiovascular diseases in patients with schizophrenia.