岩藻多糖抗病毒作用研究进展

Recent Progress in The Antiviral Activities of Fucoidan

目的:探究岩藻多糖抗病毒活性和构效关系及其作用机制。方法:以岩藻多糖、褐藻多糖硫酸酯、生物活性、抗病毒为检索词在PubMed、Web of Science、中国知网、万方数据库和维普数据库等数据库查找相关文献进行归纳整理。结果:岩藻多糖通过干扰病毒吸附、转录、合成的过程和增强机体免疫力,对SARS、流感、肝炎、疱疹、艾滋病等致病病毒发挥抑制活性。结论:岩藻多糖具有抗病毒的重要作用,本文为岩藻多糖的开发利用及抗病毒药物的研发提供科学依据。

【Objective】To explore the antiviral activity,structure-activity relationship and mechanism of fucoidan.【Method】Relevant literature were searched in PubMed,Web of Science,CNKI,Wanfang and VIP database by using the terms of fucoidan,biological activity and antiviral.【Result】By interfering with the process of virus adsorption,transcription,synthesis and enhancing the body's immunity,fucoidan had inhibitory activity against SARS,hepatitis,AIDS,influenza and herpes.【Conclusion】Fucoidan has an important antiviral ef-fect.This study can provide theoretical support for the development and utilization of fucoidan and the research of antiviral drugs.