绿茶与口腔癌发病风险的Meta分析

Meta-Analysis of Green Tea and Risk of Oral Cancer

目的:系统评价绿茶与口腔癌发病风险的关系。方法:计算机检索中国期刊全文数据库、万方数据库、维普数据库、中国生物医学文献数据库、The Cochrane Library、PubMed、Web of Science、Embase数据库,检索时限为建库至2023年4月30日,采用RevMan5.4进行Meta分析。结果:共纳入12篇文献,样本量(病例/对照)共有4 259/45 141人。Meta分析结果显示,绿茶摄入是口腔癌发生的保护性因素[OR=0.86,95%CI=(0.78,0.94),P=0.002];摄入量≥500 mL [OR=0.67,95%CI=(0.56,0.80),P<0.000 1]、年限≥20年[OR=0.56,95%CI=(0.42,0.77),P=0.000 3]、浓度适中[OR=0.58,95%CI=(0.48,0.69),P<0.000 01]、温茶[OR=0.40,95%CI=(0.29,0.53),P<0.000 01]是口腔癌发生的保护因素;牛奶与绿茶的饮用呈协同保护作用[OR=0.44,95%CI=(0.35,0.56),P<0.000 01]。结论:绿茶摄入是口腔癌发生的保护因素;牛奶的饮用可与绿茶呈协同作用;建议坚持长期饮茶,每天绿茶摄入量≥500 mL,注意浓度、温度适宜。

【Objective】To clarify the relationship between green tea and the risk of oral cancer through meta-analysis.【Method】We searched databases including CNKI、Wanfang、VIP、CBM、The Cochrane Library、PubMed、Web of Science and Embase from inception to April 30,2023.Rev Man 5.4 software was used for meta-analysis.【Result】A total of 12 papers were included,with a total sample size(cases/controls)of 4259/45141.Meta-analysis revealed that green tea intake was a protective factor for oral cancer development[OR=0.86,95%CL=(0.78,0.94),P=0.002].intake≥500 mL[OR=0.67,95%CL=(0.56,0.80),P<0.0001],years≥20 years[OR=0.56,95%CL=(0.42,0.77),P=0.0003],green tea moderate concentration[OR=0.58,95%CL=(0.48,0.69),P<0.00001],and warm tea[OR=0.40,95%CI=(0.29,0.53),P<0.00001]were protective factors for oral carcinogenesis;milk and green tea consumption were synergistically protective[OR=0.44,95%CL=(0.35,0.56),P<0.00001].【Conclusion】Green tea intake is a protective factor against oral cancer;milk consumption can have a synergistic effect with green tea;it is recommended to insist to long-term tea consumption,with a daily green tea intake of≥500mL,and pay attention to the appropriate concentration and temperature.