成人吸入性一氧化氮治疗及其临床应用进展

Progress on the treatment and clinical application of inhaled nitric oxide in adults

一氧化氮是血管内皮细胞产生的天然血管扩张因子。目前吸入性一氧化氮(iNO)已获批用于新生儿持续性肺动脉高压治疗,而对于成人患者,iNO治疗已在右心导管术期间急性肺血管反应试验中被证实有明确作用。近年来随着对iNO研究的深入,更多的疾病能从iNO治疗中获益。本文就iNO的作用机制及其相关临床应用进展作一综述,以进一步加深对iNO的生理效应及其在成人中临床应用效果的了解。

Nitric oxide is a natural vasodilator produced by vascular endothelial cells.Inhaled nitric oxide(iNO)is currently approved for the treatment of persistent pulmonary hypertension of the newborn.In adults,iNO therapy has been validated for its definite efficacy on acute pulmonary vascular response testing during right heart catheterization.In recent years,with the deepening of iNO research,iNO therapy has been able to benefit various diseases.This article reviewes the mechanism of iNO and its related clinical applications,thus further deepening the understanding of its physiological effects of iNO and clinical application in adults.