肺腺癌肿瘤标记物的性别差异分析

Gender Difference Analysis of Tumor Markers in Lung Adenocarcinoma

目的探究肿瘤标记物在肺腺癌中的性别差异,为肺腺癌精准化医疗提供相关依据。方法收集2020年01月01日—2022年1月1日在延边大学附属医院胸外科就诊,经手术明确病理诊断为肺腺癌患者168例,其中男性52例,女性116例。于延边大学附属医院检验科测定肿瘤标记物,查阅相关住院病历获得资料。基于SPSS 23.0统计软件进行数据分析。结果男性肿瘤标记物阳性率由高到低分别是细胞角蛋白19片段(Cyfra21-1)、神经元特异性烯醇化酶(NSE)、胃泌素释放肽前体(ProGRP)、癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)、糖类抗原153(CA153);女性肿瘤标记物阳性率由高到低分别是:NSE、Cyfra21-1、CA125、ProGRP、CEA、CA199、CA153;不同性别阳性肿瘤标志物具有差异的是Cy⁃fra21-1(P<0.05)。结论肺腺癌患者中Cyfra21-1存在性别差异,可作为肺腺癌精准化医疗参考指标。

Objective To explore the gender differences of tumor markers in lung adenocarcinoma and provide a relevant basis for precise medical treatment of lung adenocarcinoma.Method From January 1,2020 to January 1,2022,168 patients with lung adenocarcinoma di⁃agnosed by pathology at the Department of Thoracic Surgery of Yanbian University Affiliated Hospital were collected,including 52 males and 116 females.Tumor markers were measured at the Laboratory of Yanbian University Affiliated Hospital and relevant inpatient medi⁃cal records were consulted to obtain information.Conduct data analysis based on SPSS 23.0 statistical software.Results The positive rates of male tumor markers ranged from high to low,including cytokeratin 19 fragment(Cyfra21-1),neuron-specific enolase(NSE),gas⁃trin releasing peptide precursor(ProGRP),carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),carbohydrate antigen 125(CA125),and carbohydrate antigen 153(CA153);The positive rates of female tumor markers ranged from high to low,are:NSE,Cy⁃fra21-1,CA125,ProGRP,CEA,CA199,and CA153;The difference in positive tumor markers between different genders was found in Cy⁃fra21-1(P<0.05).Conclusion There is a gender difference in Cyfra21-1 among lung adenocarcinoma patients,which can serve as a precise medical reference indicator for lung adenocarcinoma.