自体富血小板血浆联合臭氧治疗军事训练所致踝关节创伤性关节炎的效果及对骨代谢指标的影响

Effect of platelet rich plasma combined with ozone in the treatment of traumatic arthritis of ankle joint caused by military training and its influence on bone metabolism indexes

目的探讨自体富血小板血浆(PRP)联合臭氧治疗军事训练所致踝关节创伤性关节炎的效果及对骨代谢指标的影响。方法选取2019年3月至2022年4月收治的92例踝关节创伤性关节炎患者为研究对象,按照随机数字表法将其分为对照组与观察组,各46例。对照组采用臭氧治疗,观察组在对照组基础上增加PRP治疗。比较两组的治疗效果。结果治疗后,观察组的美国骨科医师学会(AAOS)足踝量表、美国骨科足踝外协会(AOFAS)踝-后足评分均高于对照组,视觉模拟评分(VAS)评分低于对照组(P<0.05)。治疗后,观察组的骨钙素(BGP)水平高于对照组,总Ⅰ型胶原氨基端延长肽(TPⅠNP)、抗酒石酸盐酸性磷酸酶(TRAP)水平低于对照组(P<0.05)。治疗后,观察组的白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、基质金属蛋白酶-3(MMP-3)水平低于对照组(P<0.05)。结论PRP联合臭氧治疗军事训练所致踝关节创伤性关节炎的效果显著,可调节骨代谢指标,抑制炎症反应。

Objective To investigate the effect of platelet rich plasma(PRP)combined with ozone in the treatment of traumatic arthritis of ankle joint caused by military training and its influence on bone metabolism indexes.Methods A total of 92 patients with traumatic arthritis of ankle joint admitted from March 2019 to April 2022 were selected as the research objects,and the patients were divided into control group and observation group according to the random number table method,with 46 cases in each group.The control group was treated with ozone,and the observation group was treated with PRP on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the scores of American Academy of Orthopaedic Surgeons Outcomes Instruments(AAOS)ankle scale and American Orthopedic Foot and Ankle Society(AOFAS)ankle-hindfood in the observation group were higher than those in the control group,and the Visual Analogue Scale(VAS)score was lower than that in the control group(P<0.05).After treatment,the level of bone glutamyl protein(BGP)in the observation group was higher than that in the control group,and the levels of total procouagen typeⅠN-terminal propeptide(TPⅠNP)and tartrate resistant acid phosphatase(TRAP)were lower than those in the control group(P<0.05).After treatment,the levels of interleukin-1β(IL-1β),interleukin-6(IL-6)and matrix metalloproteinase-3(MMP-3)in the observation group were lower than those in the control group(P<0.05).Conclusion PRP combined with ozone is effective in the treatment of traumatic arthritis of the ankle joint caused by military training,which can regulate bone metabolism indexes and inhibit the inflammatory response.