精神分裂症患者血清非酶类抗氧化物水平与临床特征关联性研究

Correlations between serum levels of non-enzymatic antioxidants and clinical characteristics in patients with schizophrenia

目的分析精神分裂症患者血清总胆红素、白蛋白、尿酸水平与临床特征的关联性。方法选取133例精神分裂症患者为研究组,周边120名健康居民作为对照组,检测和评估患者在治疗前后的血清总胆红素、白蛋白、尿酸浓度、阳性与阴性症状量表(PANSS)评分,分析比较血清非酶类抗氧化物水平与临床特征的关联性。结果研究组男性发病年龄早于女性(P<0.01);男性患者入组时总胆红素浓度高于女性(P<0.01);男性患者治疗前及治疗后第8周末尿酸浓度均高于女性患者(P<0.001)。对照组男性尿酸浓度高于女性(P<0.001)。研究组治疗前,男性PANSS总分及阳性量表、阴性量表、一般精神病理量表评分均高于女性(P<0.05);治疗后第8周末,男性PANSS阴性量表分高于女性患者,一般精神病理量表分低于女性患者(P<0.05)。研究组治疗前血清白蛋白浓度与年龄呈负相关(P<0.001),血清尿酸浓度与发病年龄呈负相关(P<0.05);治疗后第8周末,血清尿酸浓度与发病年龄呈负相关(P<0.05),与总病程、PANSS总分和阴性量表分均呈正相关(P<0.05)。结论精神分裂症患者的非酶类抗氧化物浓度在疾病发生发展过程中与临床特征存在一定关联性,性别差异与抗氧化能力有相关性,应尽早关注这些影响因素,做到早预防早治疗。

Objective To explore the correlations among serum levels of total bilirubin,albumin,uric acid and clinical characteristics in patients with schizophrenia.Methods A total of 133 schizophrenics in study group and 120 healthy residents in control group were selected and examined with the levels of total bilirubin,albumin and uric acid before and after treatment.The study group was assessed with Positive and Negative Syndrome Scale(PANSS).And the correlation between serum levels of non-enzymatic antioxidants and clinical characteristics was analyzed.Results In study group,the onset age in males was earlier than that in females(P<0.01);the total bilirubin concentration in males before treatment was higher than that in females(P<0.01);the uric acid concentrations in males before and after treatment were all higher than those in females(P<0.001).In control group,the uric acid concentration in males was higher than that in females(P<0.001).Before treatment,the total score and factor scores of positive symptom,negative symptom and general psychopathology of PANSS in males were all higher than those in females(P<0.05).After 8 weeks of treatment,the factor score of negative symptom of PANSS in males was higher than that in females,and the factor score of general psychopathology of PANSS in males was lower than that in females(P<0.05).Before treatment,correlation analysis found that in study group there was a negative correlation between serum albumin concentration and age(P<0.001),and a negative correlation between serum uric acid concentration and onset age(P<0.05).After 8 weeks of treatment,serum uric acid concentration was negatively correlated with onset age(P<0.05),and positively correlated with total disease course,total score and factor score of negative symptom of PANSS(P<0.05).Conclusion The concentrations of non-enzymatic antioxidants in patients with schizophrenia are associated with clinical characteristics during the development of the disease.There is a difference in antioxidant capacity between males and females.It is important to pay attention to these influencing factors so as to achieve early prevention and treatment.