坦索罗辛联合丁溴东莨菪碱治疗体外冲击波碎石术后单发肾结石的临床效果观察

Observation on clinical effect of tamsulosin combined with scopolamine butylbromide in the treatment of single kidney stone disease after extracorporeal shock wave lithotripsy

目的观察丁溴东莨菪碱联合坦索罗辛治疗体外冲击波碎石术后单发肾结石的临床效果。方法选取70例单发肾结石患者纳入本研究,以随机数字表法分成对照组与试验组,每组35例。两组患者均接受体外冲击波碎石术治疗,对照组术后给予丁溴东莨菪碱促进结石排出,试验组术后给予丁溴东莨菪碱+坦索罗辛促进结石排出。治疗后,对比两组患者治疗效果、结石排出时间、肾绞痛消失时间、炎症指标改善情况以及治疗安全性。结果治疗后,试验组治疗总有效率100.00%高于对照组的80.00%(P<0.05);试验组结石排出时间、肾绞痛消失时间分别为(8.31±9.76)、(7.08±0.47)d,短于对照组的(13.66±2.33)、(10.55±0.78)d(P<0.05);试验组肿瘤坏死因子-α(TNF-α)(43.25±3.15)ng/L、白细胞介素-6(IL-6)(23.84±2.32)ng/L、C反应蛋白(CRP)(39.88±3.19)mg/L均低于对照组的(53.36±3.76)ng/L、(29.77±2.77)ng/L、(48.92±3.44)mg/L(P<0.05);两组治疗期间不良反应发生率对比,差异无统计学意义(P>0.05)。结论对接受体外冲击波碎石术治疗的单发肾结石患者术后应用丁溴东莨菪碱联合坦索罗辛治疗具有显著临床效果,可有效缩短结石排出时间、肾绞痛消失时间,炎性程度得到抑制,且并未增加用药不良反应发生风险,临床应用价值显著。

Objective To observe the clinical effect of tamsulosin combined with scopolamine butylbromide in the treatment of single kidney stone disease after extracorporeal shock wave lithotripsy.Methods 70 patients with single kidney stone disease were enrolled in this study.They were randomly divided into a control group and a test group according to random numerical table,with 35 cases in each group.The patients in both groups received extracorporeal shock wave lithotripsy.The control group was given scopolamine butylbromide to promote the excretion of stones after surgery,and the test group was given scopolamine butylbromide+tamsulosin to promote the excretion of stones after surgery.After treatment,the treatment effect,stone discharge time,disappearance time of renal colic,improvement of inflammatory markers and treatment safety of the two groups were compared.Results After treatment,the total effective rate of 100.00%in the test group was higher than 80.00%in the control group(P<0.05).The stone discharge time and the disappearance time of renal colic in the test group were(8.31±9.76)and(7.08±0.47)d,which were shorter than(13.66±2.33)and(10.55±0.78)d in the control group(P<0.05).The test group had tumor necrosis factor-α(TNF-α)of(43.25±3.15)ng/L,interleukin-6 of(23.84±2.32)ng/L,C-reactive protein(CRP)of(39.88±3.19)mg/L,which were lower than(53.36±3.76)ng/L,(29.77±2.77)ng/L,(48.92±3.44)mg/L in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion Tamsulosin combined with scopolamine butylbromide has significant clinical effect in the treatment of single kidney stone disease patients who received extracorporeal shock wave lithotripsy.It can effectively shorten the stone discharge time,the disappearance time of renal colic,inhibit the degree of inflammation,and does not increase the risk of adverse drug reactions.Its clinical application value is significant.