IL-13Ra2在肺动脉高压诊断中的作用

The function of IL-13Ra2 in the diagnosis of pulmonary arterial hypertension

目的 通过探讨白细胞介素-13受体alpha-2(IL-13Ra2)在肺动脉高压患者血清中表达以分析其诊断和评估作用。方法 2021年3月至2023年3月在盐城市第一人民医院收集36例非肺动脉高压患者及36例肺动脉高压患者的血清和临床资料,通过酶联免疫吸附试验(ELISA)检测血清中IL-13Ra2的表达量,并分析IL-13Ra2在血清中的表达量与临床资料的相关性。结果 分析两组患者临床信息发现有房颤合并症的患者更容易发生肺动脉高压(P <0.05)。肺动脉高压患者血清中IL-13Ra2的表达增高,ROC曲线下面积(AUC)为0.857,灵敏度为58.33%,特异度为97.22%,其在血清中的表达量不受其他因素的影响。结论 IL-13Ra2可作为肺动脉高压患者诊断的一种独立生物标志物。

Objective To investigate the expression of interleukin-13 receptor subunit alpha-2(IL-13Ra2) in serum of patients with pulmonary arterial hypertension to analyze its diagnostic and evaluation function.Methods The serum and clinical data of patients with non-pulmonary arterial hypertension(n=36) and with pulmonary arterial hypertension(n=36) admitted to the Yancheng No.1 People's Hospital from March 2021 to March 2023 were collected.The expression of IL-13Ra2 in serum was detected by enzyme linked immunosorbent assay(ELISA),and the correlation between the expression of IL-13Ra2 in serum and clinical data was analyzed.Results The clinical information of the two groups of patients was analyzed,and it was found that patients with atrial fibrillation were more likely to develop pulmonary arterial hypertension(P < 0.05).The expression of IL-13Ra2 in serum of patients with pulmonary arterial hypertension was increased,and the area under the ROC curve(AUC) was 0.857,sensitivity was 58.33%,specificity was 97.22%,and its expression in serum was not impacted by other factors.Conclusion IL-13Ra2 can be used as an independent biomarker in the diagnosis of pulmonary arterial hypertension.