盐酸氨溴索联合纤维支气管镜肺泡灌洗治疗重症肺炎患者的效果

The efficacy of ambroxol hydrochloride combined with fiberoptic bronchoalveolar lavage in the treatment of patients with severe pneumonia

目的 研究在治疗重症肺炎患者中,联合使用盐酸氨溴索、纤维支气管镜肺泡灌洗的效果。方法 选取2021年1月至2022年12月南京市溧水区人民医院收治的70例重症肺炎患者,采用随机抽样法划分为两组,对照组(n=35)给予盐酸氨溴索治疗,试验组(n=35)在上述治疗基础上给予纤维支气管镜肺泡灌洗疗法,比较分析两组间临床症状消失时间、临床疗效、炎症因子水平[C反应蛋白(CRP)、白细胞计数(WBC)、白介素-1(IL-1)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子α(TNF-α)]、动脉血气分析指标[p H值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]。结果 试验组总有效率高于对照组,差异有统计学意义(P<0.05)。试验组临床症状消失时间短于对照组,差异有统计学意义(P<0.05)。治疗前两组炎症因子指标比较,差异无统计学意义(P>0.05);治疗后试验组炎症因子指标低于对照组,差异有统计学意义(P<0.05)。治疗前两组动脉血气分析指标比较,差异无统计学意义(P>0.05);治疗后试验组PaO_(2)、p H值高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。结论 盐酸氨溴索联合纤维支气管镜肺泡灌洗治疗能有效改善炎症反应与动脉血气分析指标,缩短症状消失时间。

Objective To study the effect of the combined use of ambroxol hydrochloride and fiberoptic bronchoalveolar lavage in the treatment of patients with severe pneumonia.Methods A total of 70 patients with severe pneumonia admitted to Nanjing Lishui People’s Hospital from January 2021 to December 2022 were enrolled,and divided into two groups using a random sampling method.The control group (n=35) received ambroxol hydrochloride treatment,while the test group (n=35) received fiberoptic bronchoalveolar lavage treatment based on the above treatment.The time for clinical symptom disappearance,clinical efficacy,inflammatory factor levels (C-reactive protein[CRP],white blood cell count[WBC],interleukin-1[IL-1],interleukin-6[IL-6],interleukin-8[IL-8],tumor necrosis factor-α[TNF-α]),and arterial blood gas analysis indicators (p H value,partial pressure of oxygen[Pa O_(2)],partial pressure of carbon dioxide[Pa CO_(2)]) were compared and analyzed between the two groups.Results The total effective rate of the test group was higher than that of the control group,with statistically significant difference (P<0.05).After comparison,the time for clinical symptom disappearance in the test group was shorter than that in the control group,with statistically significant difference (P<0.05).Before treatment,the inflammatory factor indicators were compared between the two groups,without statistically significant difference (P>0.05).After treatment,the inflammatory factor indicators in the test group were lower than those in the control group,with statistically significant difference(P<0.05).Before treatment,the arterial blood gas analysis indicators between two groups,without statistically significant difference (P>0.05),but after treatment,the Pa O_(2) and p H values of the test group were higher than those of the control group,while Pa CO_(2) was lower than that of the control group,with statistically significant difference (P<0.05).Conclusion The ambroxol hydrochloride combined with fiberoptic bronchoalveolar lavage can effectively improve inflammatory response and arterial blood gas analysis indicators,and shorten the time for symptom disappearance.