雷公藤多苷片联合缬沙坦治疗慢性肾小球肾炎合并高血压的效果分析

Effect of Tripterygium Glycoside Tablets Combined with Valsartan on Chronic Glomerulonephritis Complicated with Hypertension

目的:分析慢性肾小球肾炎(CGN)合并高血压患者应用雷公藤多苷片联合缬沙坦的效果。方法:选取2022年1月—12月于如东洋口医院肾内科接受治疗的60例CGN合并高血压患者作为研究对象,依据随机数字表法分为对照组与观察组,每组30例。对照组采用缬沙坦治疗,观察组采用雷公藤多苷片联合缬沙坦治疗。比较两组治疗效果。结果:治疗后,观察组治疗总有效率、舒张压、收缩压、白细胞介素-4水平及肾小球滤过率高于对照组,白细胞介素-6、肿瘤坏死因子-α、C反应蛋白水平、肌酐、尿素氮、24 h尿蛋白水平低于对照组,差异有统计学意义(P<0.05)。结论:CGN合并高血压患者应用雷公藤多苷片联合缬沙坦的效果显著,可改善其血压水平、炎性状态及肾功能。

Objective:To analyze the effect of tretinoin tablets combined with valsartan in patients with chronic glomerulonephritis(CGN) combined with hypertension..Methods:Sixty patients with CGN combined with hypertension who were treated in the Department of Nephrology of Rudong Yangkou Hospital from January 2022 to December 2022 were selected as the study subjects,and were divided into the control group and the observation group based on the randomized numerical table method,each of which consisted of 30 cases.Results:After treatment,the total effective rate of treatment,diastolic blood pressure,systolic blood pressure,interleukin-4 level and glomerular filtration rate of the observation group were higher than those of the control group.,and the levels of interleukin-6,tumor necrosis factor-alpha,C-reactive protein,creatinine,urea nitrogen,and 24 h urinary protein were lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Application of tretinoin tablets combined with valsartan in patients with CGN combined with hypertension was effective in improving their blood pressure level,inflammatory state and renal function.