摘要
“海藻酸盐微胶囊的制备、药物包封及缓控释分析实验”是II型分析化学实验中非常典型的一个研究型实验,它涵盖了微胶囊形成原理探究、实验条件设计、微胶囊性能表征等科研基本能力的训练。将海藻酸钠与亚甲基蓝混合溶液分别滴加至3%CaCl2溶液和1%壳聚糖溶液中,从而制备出两种不同性能的微胶囊。通过分光光度法测得不同时间溶液的浓度,从而得到缓释曲线,并对两种胶囊的缓释性进行对比分析。后续探究实验采用一步法和两步法制备微胶囊,将两种体系的优点结合起来,得到缓释性和稳定性均较好的微胶囊。
The“Alginate microcapsule preparation,drug encapsulation,and sustained controlled release analysis experiment”serves as a prominent research-oriented experiment within Type II analytical chemistry experiments.It encompasses essential training in basic scientific research skills,including the exploration of microcapsule formation principles,experimental condition design,and microcapsule performance characterization.In this experiment,a mixed solution of sodium alginate and methylene blue was dropped into 3%CaCl2 solution and 1%chitosan solution,respectively,resulting in the preparation of two microcapsules with distinct properties.The concentration of the solution was measured at various time intervals using spectrophotometry to derive sustained-release curves,facilitating a comparative analysis of the sustained-release properties of the two microcapsules.Additionally,a subsequent exploration experiment employed both one-step and two-step methods for microcapsule preparation,combining the advantages of both systems to achieve microcapsules with optimal sustained-release and stability characteristics.
作者
胡国梁
颜鑫灏
陈睿希
刘红瑜
姚奇志
李娇
李玲玲
Guoliang Hu;Xinhao Yan;Ruixi Chen;Hongyu Liu;Qizhi Yao;Jiao Li;Lingling Li(National Demonstration Center for Experimental Chemistry Education(University of Science and Technology of China),Hefei 230026,China.;School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026,China.)
出处
《大学化学》
CAS
2024年第1期134-141,共8页
University Chemistry
基金
2021年安徽省课程思政建设示范中心(2021kcszsfzx028)
中国科学技术大学2021年校级课程思政研究项目(2021xkcszxm02)。
关键词
海藻酸盐
微胶囊
缓释曲线
一步法
两步法
Alginate
Microcapsule
Sustained-release curve
One-step method
Two-step method
