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糖尿病周围神经病变中高糖诱导背根神经节细胞凋亡的研究

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摘要 糖尿病周围神经病变(Diabetic peripheral neu-ropathy,DPN)是糖尿病(Diabetes mellitus,DM)的微血管并发症之一[1]。症状从足部开始,表现为麻木、刺痛、疼痛或虚弱,并以长度依赖的方式向近端扩散,呈对称、长袜和手套模式分布,感觉症状比运动受累更突出[2]。是最常见的神经病变类型之一,也是导致DM溃疡和截肢的重要原因,对患者的生活质量、身心健康造成了重大影响[3]。
出处 《长治医学院学报》 2024年第1期73-76,80,共5页 Journal of Changzhi Medical College
基金 国家自然科学基金面上项目(81571664) 湖北省重点研发计划(大健康领域支持地方专项)(2022BCE051)。
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  • 1乐宏元,宋小兴,刘和平.一氧化碳血红蛋白双波长定量测量[J].临床检验杂志,1996,14(2):87-88. 被引量:92
  • 2McHugh JM, McHugh WB. Diabetes and peripheral sensory neurons: what we don't know and how it can hurt us [ J ]. AACN Clin Issues, 2004, 5 : 136 - 149.
  • 3Russell JW, Sullivan KA, Windebank A J, et al. Neurons undergo apoptosis in animal and cell culture models of diabetes [ J ]. Neurobiol Dis, 1999, 6:347 - 363.
  • 4Russell JW, Golovoy D, Vincent AM, et al. High glucoseinduced oxidative stress and mitochondrial dysfunction in neurons [ J ]. FASEB J, 2002, 16 : 1738 - 1748.
  • 5Vincent AM, Stevens M J, Backus C, et al. Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury [ J ]. Antioxid Redox Signal, 2005, 7 : 1494 - 1506.
  • 6Gardiner NJ, Wang Z, Luke C, et al. Expression of hexokinase isoforms in the dorsal root ganglion of the adult rat and effect of experimental diabetes [ J ]. Brain Res, 2007, 1175:143 - 154.
  • 7Kozlova EN, Jansson L. In vitro interactions between insulin-producing beta cells and embryonic dorsal mot ganglia [J]. Pancreas, 2005, 31:380-384.
  • 8Edwards JL, Quattrini A, Lentz SI, et al. Diabetes regulates mitochondrial biogenesis and fission in mouse neurons [J]. Diabetologia, 2010, 53: 160-169.
  • 9Vincent AM, McLean LL, Backus C, et al. Short-term hyperglycemia produces oxidative damage and apoptosis in neurons[J]. FASEB J, 2005, 19:638 -640.
  • 10Ozttirk G, Erdogan E, Ozttirk M, et al. Differential analysis of effect of high glucose level in the development of neuropathy in a tissue culture model of diabetes mellitus: role of hyperosmolality [ J ]. Exp Clin Endocrinol Diabetes, 2008, 116:582-591.

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