帕金森病冻结步态的病理生理及神经机制研究进展

Research progress on the pathophysiology and neural mechanisms of freezing of gait in Parkinson's disease

冻结步态(FOG)是一种致残性的步态障碍,多见于中晚期帕金森病患者,可导致跌倒或受伤,严重影响患者的生活质量及社会功能。目前帕金森病冻结步态发病的病理生理及神经机制尚未完全明确,现有的治疗策略效果较差。本文就帕金森病冻结步态的病理生理及神经机制的研究进展进行综述。

Freezing of gait(FOG) is a disabling gait disorder' which is more common in patients with intermediate and advanced Parkinson's disease.It can lead to falls or injuries,seriously affecting the quality of life and social function of patients.At present,the pathophysiology and neural mechanisms of FOG in Parkinson's disease are not fully understood,and the available treatment strategies for FOG are poorly effective.This article reviews the research progress on the pathophysiology and neural mechanisms of FOG in Parkinson's disease.