上海市全人群出生队列的创建及概况

Design and baseline characteristics of a population-based birth cohort in Shanghai

【目的】介绍上海市全人群出生队列的基本设计思路、建设方案和建设目标,以及队列收集的主要数据和入组人群的基线特征,为未来生殖和健康相关领域研究提供重要信息参考。【方法】上海市全人群出生队列以2005年1月1日为起点,纳入每年在上海出生的新生儿及其父母,运用信息化数据链接技术,结合现场调查的方式,收集生殖健康、生殖治疗、出生特征、生长发育状况,以及疾病的发病、治疗和死亡等信息,形成全生命周期的出生队列。【结果】截至2022年10月,共纳入2978538名出生儿童及其父母,其中自然受孕子代2905135(97.54%)人,辅助生殖子代73403(2.46%)人。辅助生殖治疗夫妇中,女性平均年龄为(32.56±4.12)岁,男性为(34.62±5.34)岁,高于自然受孕夫妇的(28.02±4.71)岁和(30.07±5.54)岁。辅助生殖治疗夫妇中≥30岁的女性和男性占比分别为77.12%和85.08%,高于自然受孕夫妇的35.28%和49.66%。大学及以上学历占比分别为73.23%和73.66%,高于自然受孕夫妇的49.98%和50.91%。辅助生殖子代多胎占比33.81%,高于自然受孕子代的1.88%。子代早产、低出生体重发生率分别为24.47%和19.08%,高于自然受孕子代的5.47%和3.73%。【结论】上海市全人群出生队列全面收集在上海出生的新生儿及其父母的生殖和健康相关信息,可为研究生命早期遗传、环境、生殖治疗等因素相互作用是否对后代健康产生影响提供重要信息参考。

[Objective]To introduce the basic design,development plan and objectives of a population-based birth cohort in Shanghai,and further present the main data and baseline characteristics of enrolled participants in the cohort,and to provide key information for reproductive health-related studies.[Methods]The Shanghai population-based birth cohort initiated on January 1,2005,included newborns born in Shanghai every year and their parents,and collected information on reproductive health,reproductive treatment,birth characteristics,growth and development status,as well as the incidence,treatment and death of diseases by employing data linkage technology and investigations.This formed a birth cohort spanning the entire life cycle.[Results]As of October 2022,a total of 2978538 newborns and their parents were included in the cohort.Among them,2905135(97.54%)were naturally conceived(NC),and 73403(2.46%)were born through assisted reproductive technologies(ART).The average age of parents was(32.56±4.12)years old for females and(34.62±5.34)years old for males in the ART group,which was higher than(28.02±4.71)years and(30.07±5.54)years for parents in the NC group.Among parents,females and males aged 30 and above accounted for 77.12%and 85.08%,respectively,which were higher than that of parents(35.28%for females and 49.66%for males)in the NC group.Furthermore,the percentage of parents with a college degree or above in the ART group was 73.23%for females and 73.66%for males,which were higher than those in the NC group(49.98%and 50.91%,respectively).The multiple births rate in the ART group was 33.81%,which was higher than that in the NC group(1.88%).The incidence of premature birth and low birth weight in the ART group were 24.47%and 19.08%,respectively,which was higher than that in the NC group(5.47%and 3.73%).[Conclusion]The comprehensive collection of reproductive health-related information in the birth cohort in Shanghai can provide essential resources to determine the influence of genetics,environment,reproductive treatment and other related factors on the health of offspring after birth.