探讨妊高征患者行硝苯地平联合小剂量阿司匹林治疗的效果

To investigate the effect of nifedipine combined with low dose aspirin in patients with PIH

目的 分析妊娠期高血压综合征(妊高征)特点,评价硝苯地平联合小剂量阿司匹林进行治疗的效果。方法 选取60例妊高征患者,根据随机抽签法分为两组,每组30例。对照组行硝苯地平治疗,研究组在对照组基础上联合小剂量阿司匹林治疗。比较两组临床效果。结果 研究组总有效率100%明显高于对照组的73.33%(P<0.05)。相比治疗前,治疗后两组收缩压、舒张压水平降低,且研究组明显低于对照组,差异具有统计学意义(P<0.05)。相比治疗前,治疗后两组血浆凝血酶原时间较长,血浆纤维蛋白原、D-二聚体指标降低,且研究组明显优于对照组,差异具有统计学意义(P<0.05)。研究组不良妊娠结局发生率低于对照组(P<0.05)。结论 对比单纯的硝苯地平治疗,联合小剂量阿司匹林治疗后,可以促进患者凝血功能改善,降低血压水平,提升治疗效果,从而改善母婴不良结局,值得临床推广。

Objective To analyze the characteristics of pregnancy induced hypertension syndrome(PIH) and evaluate the effect of nifedipine combined with low-dose aspirin.Methods 60 patients with PIH were selected and divided into two groups with 30 cases in each group according to random drawing method.The control group was treated with nifedipine,while the study group was treated with low-dose aspirin.The clinical effect of the two groups was compared.Results The total effective rate of 100% in the study group was significantly higher than that of 73.33% in the control group(P<0.05).Compared with before treatment,the systolic blood pressure and diastolic blood pressure of the two groups were decreased after treatment,and the study group was significantly lower than the control group,the difference was statistically significant(P<0.05).Compared with before treatment,plasma prothrombin time was longer,plasma fibrinogen and D-dimer indexes were decreased in the two groups after treatment,and the study group was significantly better than the control group,the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcome in study group was lower than that in control group(P<0.05).Conclusion Compared with simple nifedipine treatment,combined with low-dose aspirin treatment,it can promote the improvement of coagulation function in patients,reduce blood pressure level,improve the therapeutic effect,and thus improve the adverse outcome of maternal and infant,which is worthy of clinical promotion.