0.01%阿托品滴眼液在儿童青少年近视中应用有效性及安全性

Efficacy and safety of 0.01% atropine eye drops in children and adolescents with myopia

目的探讨0.01%阿托品滴眼液在儿童青少年近视中应用的有效性及安全性。方法选取2022年1—12月于自贡市第一人民医院眼视光门诊就诊的80例(160眼)儿童青少年近视患者为研究对象。根据治疗方法不同,将患者分入常规组和联合组,每组各40例。联合组:0.01%阿托品滴眼液每晚睡前使用1次,每次1滴,使用6个月;根据屈光度大小及视力需求戴框架眼镜。常规组:仅戴框架眼镜。两组随访观察6个月。比较两组用药前后的眼轴长度、屈光度及安全性指标,并观察不良反应发生情况。结果用药后,常规组和联合组的眼轴长度、屈光度均较用药前增加,且常规组大于联合组,差异有统计学意义(P<0.05)。用药后,常规组和联合组的瞳孔直径较用药前增加,且联合组大于常规组,差异有统计学意义(P<0.05)。用药后,常规组和联合组的调节灵活度、泪膜破裂时间、泪液分泌量、泪河高度较用药前减小,且联合组小于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论0.01%阿托品滴眼液可有效减缓近视儿童青少年眼轴及近视度数的增长,控制儿童青少年近视进展,且安全性佳。

Objective To investigate the efficacy and safety of 0.01% atropine eye drops in the treatment of myopia in children and adolescents.Methods 80 cases(160 eyes)of children and adolescents with myopia treated in the First People′s Hospital of Zigong from January to December 2022 were selected as the study objects.According to different treatment methods,the patients were divided into conventional group and combined group,with 40 cases in each group.Combined group:0.01% atropine eye drops were used once a night before going to bed,1 drop each time for 6 months and wore frame glasses according to diopter and vision needs.Conventional group:wore frame glasses only.Both groups were followed up for 6 months.The axial length,diopter and safety indexes of the two groups were compared before and after treatment,and the occurrence of adverse reactions was observed.Results After treatment,the axial length and diopter of the eye in the conventional group and the combined group were increased compared with that before treatment,and the conventional group was greater than the combined group,the difference was statistically significant(P<0.05).After medication,the pupil diameter of the conventional group and the combined group increased compared with that before medication,and the combined group was larger than the conventional group,the difference was statistically significant(P<0.05).After medication,the regulatory flexibility,tear film rupture time,tear secretion volume and lacrimal river height of the conventional group and the combined group were decreased compared with those before medication,and the combined group was smaller than the conventional group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion 0.01% atropine eye drops can effectively slow down the growth of eye axis and myopia degree in children and adolescents with myopia,and control the progression of myopia in children and adolescents with good safety.