寻常型银屑病患者血清TARC、vWF水平与病情严重程度的相关性

Association between serum TARC,vWF levels and severity of psoriasis vulgaris patients

目的 检测并分析寻常型银屑病(PV)患者血清胸腺和活化调节趋化因子(TARC)、血管性血友病因子(vWF)水平及与病情严重程度的相关性。方法 选取2020年2月至2022年2月沧州市人民医院收治的74例PV患者(PV组),以本院同期42例健康体检者为对照组。根据病情严重程度将PV患者分为轻中度组(40例)和重度组(34例)。收集患者临床资料,采用ELISA法检测血清TARC、vWF、TNF-α和IL-8水平。比较不同病情严重程度PV患者血清TARC、vWF、TNF-α、IL-8水平及临床指标的差异。采用Pearson相关分析PV患者血清TARC、vWF与临床指标的相关性。采用logistic回归分析重度PV发生的影响因素。采用ROC曲线评估血清TARC、vWF对重度PV的诊断效能。结果 PV组血清TARC、vWF水平均高于对照组,差异均有统计学意义(均P<0.05)。重度组PV患者血清TARC、vWF、WBC、中性粒细胞计数、ESR、银屑病皮损面积和严重程度评分(PASI)、超敏C反应蛋白(hs-CRP)、TNF-α、IL-8均高于轻中度组,差异均有统计学意义(均P<0.05)。PV组患者血清TARC、vWF水平与ESR、hs-CRP、PASI评分、TNF-α、IL-8均呈显著正相关(均P<0.05)。血清TARC、vWF水平升高是重度PV发生的独立危险因素。血清TARC、vWF联合诊断发生重度PV的AUC为0.903,显著高于TARC和vWF单独诊断的0.823和0.807(均P<0.05)。血清TARC、vWF联合诊断发生重度PV的灵敏度和特异度为0.878和0.753。结论 PV患者血清TARC、vWF水平升高。两者与PV病情严重程度呈正相关,血清TARC、vWF联合检测有助于评估PV疾病严重程度。

Objective To investigate the association between serum thymus activation regulated chemokines(TARC),von Willebrand factor(vWF) levels and the disease severity in patients with psoriasis vulgaris(PV).Methods Seventy four PV patients treated at the Cangzhou People's Hospital from February 2020 to February 2022 were enrolled as PV group,and 42 healthy subjects were taken as the control group.According to the severity of disease patients were divided into mild to moderate group(40 cases) and severe group(34 cases).Serum TARC,vWF,TNF-α,IL-8 levels were measured with ELISA and compared among patients with different severity of disease.Pearson correlation analysis was used to analyze the correlation between serum TARC,vWF and clinical indexes in PV patients.Multiple logistic regression analysis was conducted to analyze the risk factors of severe PV disease;and the value of risk factors in predicting disease severity was analyzed by ROC curve.Results The serum TARC and vWF in PV group were significantly higher than those in control group(P<0.05).Serum TARC,vWF,WBC,neutrophil counts,ESR,psoriasis area and severity index(PASI),hypersensitive C-reactive protein(hs-CRP),TNF-α,IL-8 in severe PV group were significantly higher than those in mild to moderate group(all P<0.05).The serum TARC,vWF levels were positively correlated with ESR,hs-CRP,PASI score,TNF-α and IL-8 in PV group(all P<0.05).Elevated serum TARC and vWF were independent risk factors of severe PV disease.The AUC of the combined detection of serum TARC and vWF was 0.903,which was significantly higher than that of TARC and vWF alone(0.823,0.807,P<0.05).The sensitivity and specificity of serum TARC and vWF in combination to predict the severity of PV disease were 0.878 and 0.753,respectively.Conclusion The levels of serum TARC and vWF in PV patients increase,which are positively correlated with the severity of PV.The combination of serum TARC and vWF can be used to evaluate the severity of PV disease.