孟德尔随机化分析方法在结直肠癌病因研究中的应用现状

Application of Mendelian Randomization in Analyzing the Etiology of Colorectal Cancer

结直肠癌是临床常见的恶性肿瘤,早诊早治和筛查项目开展具有重要意义,发现可控的致病因素是结直肠癌防治的必要条件。孟德尔随机化分析方法借助个体的遗传信息来推断暴露与疾病的因果关联,从而反映两者之间的真实联系。该方法可以有效控制潜在的混杂因素,被广泛应用于医学各领域研究。本文将系统总结孟德尔随机化分析在结直肠癌的研究进展,为该病的病因机制研究提供科学依据。

Colorectal cancer is a clinically common malignant tumor.It is of great significance to carry out early diagnosis,early treatment and screening of colorectal cancer.Identifying controllable pathogenic factors is necessary for the prevention and treatment of colorectal cancer.Mendelian randomization analysis uses individual genetic information to infer the causal relationship between exposure and disease,thereby reflecting the true connection between the two.This method can effectively control potential confounding factors and is widely applied in various fields of medical research.This article will systematically summarize the research progress of Mendelian randomization analysis in colorectal cancer,providing scientific basis for the study of the etiology and mechanism of this disease.