80例乳腺癌患者在肝转移中的临床特征及预后效果评估

Clinical Features and Prognostic Effect Evaluation of 80 Breast Cancer Patients in Liver Metastasis

目的探讨80例乳腺癌患者的临床特征及乳腺癌肝转移预后的影响因素效果评估。方法回顾性2010年6月-2023年7月共80例经临床病理活检证实的乳腺癌病人,分析其发病年龄和病理特征及手术方式,化疗与否及手术术后发生肝脏转移的时间。经过Kaplan-Meier法对乳腺癌患者临床病理特征与乳腺癌肝转移进行单因素分析,通过Cox生存研究探析影响乳腺癌肝脏转移瘤的因素。结果Kaplan-Meier单因素探析结果表明,化疗和改良根治术与乳腺癌肝转移患者的预后有关(P<0.05);Cox模型多因素分析结果显示,化疗是乳腺癌肝转移患者的独立预后因素(P=0.046),且化疗后的患者的中位生存时间(121个月)比未化疗者的中位生存时间长(87个月)。结论乳腺癌肝脏转移瘤病人的独立预后因素是化疗,其可延长患者的生存时间。

Objective To investigate the clinical features of breast cancer patients and the influencing factors of liver metastasis of breast cancer.Methods Eighty postoperative patients with pathologically confirmed breast cancer from which year-which year were selected were retrospectively analyzed for age,clinicopathological characteristics,surgical modality,chemotherapy or not,and time to liver metastasis after surgery.Clinicopathologic characteristics of breast cancer patients and breast cancer liver metastasis were analyzed univariately by Kaplan-Meier method,and factors affecting breast cancer liver metastasis were studied by Cox survival analysis.RESULTS Kaplan-Meier univariate analysis showed that chemotherapy and modified radical surgery were associated with the prognosis of patients with liver metastases from breast cancer(P<0.05),and Cox model multivariate analysis showed that chemotherapy was an independent prognostic factor for patients with liver metastases from breast cancer(P=0.046)and that the median survival time of patients treated with chemotherapy(121 months)was longer than that of those who were not treated with chemotherapy(87 months).Conclusion Chemotherapy is an independent prognostic factor in patients with liver metastases from breast cancer,and it prolongs survival.