阿立哌唑联合MECT治疗男性精神分裂症的效果及对记忆和执行功能影响

Effect of Aripiprazole Combined with MECT on Male Schizophrenia and Its Effect on Memory and Executive Function

目的探究阿立哌唑联合无抽搐电休克疗法(MECT)治疗男性精神分裂症(SZ)的效果及对记忆和执行功能影响。方法选取2020年10月至2022年10月期间安阳市第七人民医院收治的93例男性SZ患者,采用随机数字表法将其分为2组,对照组46例,观察组47例,对照组给予阿立哌唑,观察组服用阿立哌唑的同时配合MECT。连续治疗6周后评估患者疗效及血清神经营养因子水平,分别采用韦氏记忆量表(WMS)、威斯康星卡片分类测验(WCST)并评估患者记忆水平及执行功能。结果观察组治疗总有效率为89.36%,高于对照组的71.74%(P<0.05)。2组患者治疗后NFG、BDNF水平均升高,观察组治疗后NFG、BDNF均高于对照组(P<0.05)。与治疗前比较,观察组治疗1周后WMS评分降低,WCST错误应答数增加(P<0.05),2组治疗6周后WMS评分均升高,WCST错误应答数减少(P<0.05);与治疗1周后比较,2组治疗6周后WMS评分均升高,WCST错误应答数均减少(P<0.05);观察组治疗1周后WMS评分低于对照组,WCST错误应答数均减少,治疗6周后WMS评分高于对照组,WCST错误应答数低于对照组(P<0.05)。结论阿立哌唑联合MECT能够提高男性SZ患者临床疗效,短期内会影响患者记忆水平及执行功能,但坚持治疗会改善记忆和执行功能。

Objective To explore the effect of aripiprazole combined with non-convulsive electroconvulsive therapy(MECT)on male schizophrenia(SZ)and its effect on memory and executive function.Methods A total of 93 male patients with schizophrenia admitted to Anyang Seventh People's Hospital from October 2020 to October 2022 were selected and divided into two groups by random number table method.There were 46 cases in the control group and 47 cases in the observation group.The control group was given aripiprazole,and the observation group was given aripiprazole combined with MECT.Efficacy and serum neurotrophic factor levels were evaluated after 6 weeks of continuous treatment.Wechsler Memory Scale(WMS)and Wisconsin Card Sorting Test(WCST)were used to evaluate the memory level and executive function of the patients.Results The total effective rate of the observation group was 89.36%,which was higher than that of the control group(71.74%)(P<0.05).NFG and BDNF levels in 2 groups were increased after treatment,and NFG and BDNF levels in observation group were higher than those in control group(P<0.05).The WMS score of the observation group was lower than before treatment after 1 week of treatment,and the number of false responses to WCST was higher than before treatment(P<0.05).WMS score was higher in 2 groups than before treatment after 6 weeks of treatment,and the number of WCST false responses was lower than before treatment(P<0.05).The WMS score of 2 groups after 6 weeks of treatment was higher than that before and after 1 week of treatment,and the number of false responses to WCST was lower than that before and after 1 week of treatment(P<0.05).The WMS score of the observation group was lower than that of the control group after 1 week of treatment,and the number of WCST false responses was higher than that of the control group,and the WMS score was higher than that of the control group after 6 weeks of treatment,and the number of WCST false responses was lower than that of the control group(P<0.05).Conclusion Aripiprazole combined with MECT can improve the clinical efficacy of male SZ patients,and will affect the memory level and executive function of patients in the short term,but adherence to treatment will improve memory and executive function.