人SLC15A3基因及蛋白质的生物信息学分析

Bioinformatic analysis of human SLC15A3 gene and protein

目的:研究SLC15A3调控和功能的完整机制。方法:通过生物信息学软件对人SLC15A3基因启动子元件和蛋白结构、理化和定位特性及其进化关系进行表征。结果:人SLC15A3基因受多种转录因子(YY1、AP-1、c-Fos、c-Jun、Sp1、NF-κB)调控。SLC15A3蛋白是由581个氨基酸残基组成的疏水不稳定蛋白,在哺乳动物中氨基酸序列有高保守性,与CD6、TYROBP、CD5、NOD2等蛋白相互作用。结论:本研究生物信息学分析结果有助于深入研究SLC15A3在炎症反应发生发展中的作用机制。

Objective:To investigate complete mechanism of SLC15A3 regulation and function.Methods:Human SLC15A3 gene promoter elements and protein structure,physio-chemical and localization properties,and its evolutionary relationships were described by bioinformatics tools.Results:Human SLC15A3 gene was regulated by multiple transcription factors(YY1,AP-1,c-Fos,c-Jun,Sp1 and NF-κB).SLC15A3 protein was a hydrophobic unstable protein composed of 581 amino acid residues,its highly conserved in mammals,and interacted with proteins such as CD6,TYROBP,CD5 and NOD2.Conclusion:This information from bio-informatics analysis will help future attempts to better understand regulation mechanisms of SLC15A3 in development of inflammatory response.