小细胞外囊泡(sEVs)介导HBV感染及相关机制的研究进展

Small extracellular vesicles(sEVs)mediate HBV infection and related mechanism research progress

小细胞外囊泡(sEVs)是由大多数细胞分泌的具有脂质双分子层的纳米级别的膜性囊泡,因其是物质交换和信号传递的重要媒介,而被研究者广泛关注。治愈乙型肝炎的基础在于充分掌握HBV复制调控分子机制,HBV主要通过与膜表面受体结合进行复制传代,但其并不是唯一传染途径,除受体途径外,sEVs可将游离的HBV传播给未感染的肝细胞。但sEVs介导HBV感染的机制并不十分明确,因此,本文主要对HBV感染后肝细胞分泌的sEVs与HBV病毒传递的关系和感染机制进行探讨,为临床上治疗HBV感染疾病提供科学的理论指导。

Small extracellular vesicles(sEVs)which are nanoscale membranous vesicles with lipid bilayers secreted by most cells,have received widespread attention from research scholars because they are important mediators of substance exchange and sig-naling.The basis of curing hepatitis B disease lies in fully understanding the molecular mechanism of HBV replication regulation.HBV mainly binds to membrane surface receptors for replication and transmission,but it is not the only route of infection.In addition to the receptor route,sEVs can transmit free viral HBV to uninfected hepatocytes.However,the mechanism of sEVs mediating HBV infec-tion is not very clear to us,therefore,this paper will focuses on the relationship between sEVs secreted by hepatocytes after HBV in-fection and the transmission of HBV virus and the mechanism of infection,so as to provide a theoretical guidance for clinical treatment of hepatitis B virus infection.