阿米巴穿孔素A的活性机制及其作为天然抗菌蛋白的潜在应用

The active mechanism of Amoebapore A and its potential application as a natural antibiotic protein

当今,抗生素耐药性已成为全球面临的严峻挑战,导致传统抗生素的疗效受到限制。抗菌蛋白是一类多样的天然抗菌分子,广泛分布于动植物和微生物中,通过与细菌相互作用破坏其完整性,从而实现杀菌作用。与传统抗生素相比,抗菌蛋白还具有增强宿主免疫响应、降低细菌耐药风险等优势。阿米巴穿孔素A(Amoebapore A,APA)是一种由阿米巴原虫分泌的古老天然抗菌蛋白,通过增加细菌细胞膜的通透性和破坏细胞结构展现广谱杀菌活性。对APA的活性机制进行概述,旨在为开发以天然抗菌蛋白为基础的新型抗生素提供理论基础,以更好地解决抗生素耐药问题。

Nowadays,antibiotic resistance has emerged as a serious global challenge,limiting the effectiveness of conventional antibiotics.Antimicrobial proteins are a diverse class of natural antimicrobial molecules found widely in animals,plants,and microorganisms.They exert bactericidal effects by disrupting bacterial integrity through interactions.In addition to traditional antibiotics,antimicrobial proteins offer advantages such as enhancing host immune responses and reducing the risk of bacterial resistance.Amoebapore A(APA)is an ancient natural antimicrobial protein secreted by Entamoeba histolytica.It exhibits broad-spectrum bactericidal activity by increasing bacterial cell membrane permeability and disrupting cell structure.This review explores the mechanism of action of APA,aiming to provide a theoretical foundation for the development of novel antibiotics based on natural antimicrobial proteins to address antibiotic resistance more effectively.