肠道菌群与多囊卵巢综合征发生发展的研究进展

Research progress on the occurrence and development of intestinal flora and polycystic ovary syndrome

多囊卵巢综合征(PCOS)发病机制复杂多样,其主要的临床表现为稀发排卵、闭经,甚至不孕,常常伴有多毛及痤疮等,而且与肥胖、胰岛素抵抗(IR)及抑郁发生密切相关,严重影响育龄女性健康。肠道微生态障碍被认为可能通过炎症和氧化应激等方面介导PCOS的发生发展,同时通过补充益生菌(包括合生元)及粪便移植(FMT)来调整肠道微生态环境可以积极缓解PCOS患者高雄激素血症(HA)、糖脂代谢异常及中枢免疫异常等临床症状,成为治疗PCOS的新思路。本文将主要从肠道菌群在PCOS发病的介导,临床症状的改善,以及应用潜力等方面进行阐述。

Polycystic ovary syndrome(PCOS)is an endocrine and metabolic disorder with complex etiology,the main clinical manifestations of which are oligoovulation,amenorrhea,and even infertility,often accompanied by hirsutism and acne,and is closely related to obesity,insulin resistance(IR)and depression,seriously affecting the health of women of childbearing age.Intestinal microbiome disorders are believed to be likely to mediate the occurrence and the development of PCOS through inflammation and oxidative stress.Adjusting the intestinal microecological environment through supplementation of probiotics(including synbiotics)and fecal transplantation(FMT)can actively alleviate the clinical symptoms of hyperandrogenemia(HA),glucose and lipid metabolism and central immune abnormalities in PCOS patients,providing a new idea for the treatment of PCOS.This review mainly focuses on the mediation role of intestinal flora on PCOS in the pathogenesis,the improvement of clinical symptoms,and its potential application.