卵巢过度刺激综合征的发病机制及预防药物研究进展

Research progress on mechanism and preventive drugs of ovarian hyperstimulation syndrome

卵巢过度刺激综合征(OHSS)是辅助生殖技术中常见的并发症之一,其发生机制尚未完全明确,内源性或外源性人绒毛膜促性腺激素(HCG)刺激卵巢释放大量的血管活性物质被认为是OHSS发病的核心环节。目前临床对OHSS的预防方法包括药物、个体化控制性促排卵、全胚冷冻、滑行疗法及未成熟卵母细胞体外成熟等手段,但仍未能完全预防OHSS的发生,且中重度OHSS对患者的生理及心理健康产生不利影响。因此,阐明OHSS的发病机制,发现可靠的预防方法,降低患者周期取消率及经济负担至关重要。本文将就OHSS的发病机制及预防药物研究进展进行综述,以期为OHSS的预防及治疗提供临床参考。

Ovarian hyperstimulation syndrome(OHSS)is one of the common complications in assisted reproductive technology,and its pathogenesis has not been fully defined.Endogenous or exogenous human chorionic gonadotropin(hCG)stimulation of the ovary to release a large number of vasoactive substances is considered to be the key element in the pathogenesis of OHSS.Currently,the clinical prevention methods for OHSS include the use of drugs,individualized controlled ovarian stimulation,freeze-all strategy,coasting therapy and in vitro maturation,but the occurrence of OHSS has not been completely prevented.Moderate to severe OHSS may adversely affect the health and outcomes of transferred patients.Therefore,it is important to elucidate the pathogenesis of OHSS,find reliable prevention methods,and reduce the cycle cancellation rate and economic burden of the patients.This paper reviews the pathogenesis and prevention of OHSS in order to provide clinical reference for the prevention and treatment of OHSS.