干细胞在卵巢组织冷冻与移植中应用的研究进展

Research progress on the application of stem cells in ovarian tissue freezing and transplantation

干细胞在血液系统疾病中的临床应用已经较为成熟,并进行了广泛推广,例如骨髓造血干细胞移植治疗白血病等,挽救了很多白血病患者的生命。然而,干细胞在生殖医学领域仍处于较慢的初期发展阶段。虽然相对而言,干细胞在卵巢功能障碍的研究已经很多,但在卵巢冷冻与移植上有很多尚未开展且值得研究的方向。本文将从干细胞在卵巢组织冷冻保存和移植方面的最新研究进展进行综述,重点介绍不同来源干细胞改善损伤性卵泡存活的进展及其机制,以及在不孕症治疗和生育能力保存尤其是在卵巢冷冻移植方面的潜在临床应用价值。

The clinical application of stem cells in the treatment of blood system diseases has been relatively mature,and has been widely promoted,which has saved the lives of many leukemia patients.However,stem cells in reproductive medicine are still in the early stage of development.Although there are relatively more studies on stem cells in ovarian dysfunction,there are many interests in ovarian freezing and transplantation that have not been conducted and worthy studying.This review summarizes the latest progress of stem cell use in cryopreservation and transplantation of ovarian tissue,highlights the progress and mechanisms of improving damaged follicle survival with stem cells from different sources,and prospects the potential clinical applications in infertility treatment and fertility preservation,especially in ovarian frozen transplantation.