铁稳态失调与肌少症相关机制

Mechanisms linking dysregulation of iron homeostasis to sarcopenia

肌少症的病因很多,发病机制复杂。近年研究显示,铁稳态失调,铁过载或者铁缺乏,均可促进肌少症的发生或发展,相关机制涉及氧化应激、线粒体、自噬、铁死亡、胰岛素抵抗和脂代谢等多种途径。本文就近年来铁稳态失调与肌少症相关机制的研究进行综述,以期为临床上肌少症的诊断和治疗提供新的思路和靶点。

There are many causes of sarcopenia,and the disease mechanism is complex.Recent studies have shown that dysregulation of iron homeostasis,iron overload or iron deficiency can promote the occurrence or development of sarcopenia,with related mechanisms including oxidative stress,mitochondria,autophagy,iron death,insulin resistance,and lipid metabolism.This article reviews recent studies on the mechanism of dysregulation of iron homeostasis and sarcopenia,providing a new idea and target for the diagnosis and treatment of sarcopenia.