训练免疫及其对儿童健康的影响

Trained immunity and its influence on children′s health

训练免疫是近10余年新出现的免疫学术语, 指固有免疫系统对再次刺激所产生的记忆免疫。训练免疫能够非特异性增强机体的免疫防御功能, 也参与过敏性炎症和自身免疫性疾病的发生。目前, 越来越多的研究开始关注训练免疫在疾病预防、治疗和发生发展等方面的作用。现就训练免疫的定义、机制、诱导剂及其对儿童健康的影响进行阐述, 以提高儿科医师对训练免疫的认识。

Trained immunity has been a novel term in immunology for over a decade,referring to the memory immunity produced by the innate immune system upon re-stimulation.Non-specific training of the immune system enhances the immune defense function and is also involved in allergic inflammation and autoimmune diseases.An increasing number of researchers are focusing on the role of immune training in the prevention,treatment,onset and progression of diseases.This review explains the definition,mechanism,and inducers of immune training and its impact on children′s health and disease,in order to enhance pediatricians′comprehension of trained immunity.