成人重度抑郁症脑白质微结构的DTI的研究

DTI Study on The Microstructure of White Matter in Adult Severe Depression

目的本研究希望在重度抑郁症患者中发现与额叶和海马体相关的脑白质微结构异常。方法利用弥散张量成像数据和基于通道的空间统计,研究了30名重度抑郁症成年人与31名健康对照者脑白质纤维束的微观结构差异,并计算了与MDD相关的微观结构变化和病程之间的关系。结果 研究发现,重度抑郁症患者的胼胝体膝部和体部、右侧放射冠和部分丘脑辐射的分数各向异性降低,提示这些区域的纤维髓鞘化水平降低,这些区域各向异性分数的降低与较长的病程有关。结论本次研究结果表明,MDD可能与关键纤维束的显微结构损伤有关,这为理解和治疗MDD提供了新的思路。

Objective In this study,we hope to find the microstructure abnormalities of white matter related to frontal lobe and hippocampus in patients with major depressive disorder.Methods Using diffusion tensor imaging data and channel-based spatial statistics,the microstructure differences of white matter fiber tracts were studied in 30 adults with major depressive disorder and 31 healthy controls.We calculated the relationship between the microstructure changes and the course of disease associated with major depressive disorder.Results It was found that the fractional anisotropy of corpus callosum knee and body,right corona and part of thalamus decreased in patients with major depressive disorder,suggesting a decrease in the level of fibrous myelination in these areas.The decrease of anisotropy in these areas is related to the longer course of disease.Conclusion The results of this study show that MDD may be related to the microstructure damage of key fiber bundles,which provides a new idea for understanding and treating MDD.