提高中药固体制剂载药量的意义与途径

Significance and Approach of Increasing Drug Loading in Solid Preparation of Traditional Chinese Medicine

载药量是评价中药固体制剂产品质量的重要指标。载药量受药物特性、剂型、工艺、体内递药的制约,影响制剂成型工艺、治疗效果以及药物释放速率。通过查阅国内外文献,本文提出了提高载药量可以提高患者的顺应性,降低生产成本,降低辅料引入的风险等意义。综述了提高载药量的可行途径,如选择高效能辅料,适合的药物制备技术,修饰药物的物理性质等,以期为高载药量,高品质制剂的开发提供理论依据。

Drug loading is an important index to evaluate the quality of solid preparation of traditional Chinese medicine.Drug loading is restricted by drug characteristics,dosage form,process,and drug delivery in vivo,which affects the preparation process,therapeutic effect,and drug release rate.By consulting domestic and foreign literature,this paper put forward the significance of increasing the drug loading:improving the compliance of patients,reducing the production cost,reducing the risk of the excipients.In this review,the possible approaches to increase drug loading,such as the selection of high-efficiency excipients,suitable drug preparation techniques,and modification of the physical properties of drugs are summarized.It will provide theoretical basis through this review for the development of high drug loading and high-quality formulations.