通神复脑丸联合西医常规治疗对后循环缺血性眩晕患者眩晕程度、血液黏度及血清D-二聚体水平的影响

Effects of Tongshen Funao pills combined with conventional western medicine on vertigo degree,blood viscosity and serum D-dimer level in patients with posterior circulation ischemic vertigo

目的观察通神复脑丸联合西医常规治疗对后循环缺血性眩晕(PCIV)患者眩晕程度、血液黏度及血清D-二聚体水平的影响。方法PCIV患者随机分为试验组与对照组。对照组给予西医常规治疗,试验组在对照组基础上加用通神复脑丸治疗。治疗2周后,观察两组临床疗效与药品不良反应,比较两组治疗前后中医症状积分、眩晕程度(眩晕评估量表、眩晕障碍调查表)、血液黏度(全血高切黏度、全血低切黏度、血浆黏度)、血清D-二聚体水平变化。结果共纳入PCIV患者87例,其中试验组44例,对照组43例。试验组总有效率为93.18%,高于对照组的76.74%(P<0.05)。治疗后,两组患者的中医症状积分、眩晕评估量表和眩晕障碍调查表评分、全血高切黏度、全血低切黏度、血浆黏度、血清D-二聚体水平等指标均较治疗前显著降低(P<0.05),且试验组各指标均低于对照组(P<0.05)。两组患者治疗期间均未出现明显不良反应。结论通神复脑丸联合西医常规治疗可有效提高PCIV临床疗效,减轻眩晕症状,改善血流动力学。

Objective To observe the effects of Tongshen Funao pills combined with conventional western medicine on vertigo degree,blood viscosity and serum D-dimer level in patients with posterior circulation ischemic vertigo(PCIV).Methods The patients with PCIV were randomly divided into test group and control group.The control group was treated with routine western medicine,and the test group was treated with Tongshen Funao pills on the basis of the control group.After 2 weeks of treatment,the clinical efficacy and drug adverse reactions were observed.Traditional Chinese medicine(TCM)symptom scores,vertigo degree[(dizziness assessment rating scale(DARS),dizziness handicap inventory(DHI)],blood viscosity(whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity)and serum D-dimer level of the two groups were compared before and after treatment.Results A total of 87 patients with PCIV were included,including 44 in the test group and 43 in the control group.The total effective rate of the test group was 93.18%,which was higher than that of the control group 76.74%(P<0.05).After treatment,the TCM symptom scores,DARS score,DHI score,whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity and serum D-dimer level in the two groups were all lower than those before treatment,and all indexes in the test group were lower than those in the control group(P<0.05).There were no obvious adverse reactions in both groups during treatment.Conclusion Tongshen Funao pills combined with conventional western medicine can effectively improve the clinical efficacy of PCIV,reduce vertigo symptoms and improve hemodynamics.