参松养心胶囊联合酒石酸美托洛尔治疗心力衰竭合并室性心律失常的有效性与安全性

The effects of Shensong Yangxin capsule combined with metoprolol tartrate on cardiac function,ventricular remodeling and safety in patients with heart failure complicated with ventricular arrhythmia

目的探究参松养心胶囊联合酒石酸美托洛尔对心力衰竭合并室性心律失常患者血流动力学、心室重构及不良反应的影响。方法纳入2019年1月至2022年12月杭州市西溪医院收治的心力衰竭合并室性心律失常患者为研究对象,按用药方案不同分为对照组和试验组。对照组患者使用酒石酸美托洛尔片治疗,试验组患者在对照组的基础上使用参松养心胶囊治疗。比较两组的心力衰竭和心律失常治疗疗效,心功能[左心室收缩末期内径(LVESD)和左心室舒张末期内径(LVEDD)]、心室重构[基质金属蛋白酶-9(MMP-9)和左心室质量指数(LVMI)]、不良反应发生率等指标。结果共纳入90例心力衰竭合并室性心律失常患者,每组各45例。试验组患者心律失常治疗总有效率(97.78%vs.86.67%,P=0.049)、心力衰竭治疗总有效率(95.56%vs.82.22%,P=0.044)均显著高于对照组。治疗前两组患者心功能指标(LVEDD、LVESD)、心室重构指标(MMP-9、LVMI)差异均无统计学意义(P>0.05);治疗后两组患者心功能指标(LVEDD、LVESD)、心室重构指标(MMP-9、LVMI)均显著降低(P<0.05)。治疗后,试验组患者心功能指标(LVEDD、LVESD)、心室重构指标(MMP-9、LVMI)均显著低于对照组(P<0.05)。结论参松养心胶囊联合酒石酸美托洛尔可有效改善心力衰竭合并室性心律失常患者血流动力学和心室重构。

Objective To investigate the effects of Shensong Yangxin capsule combined with metoprolol tartrate on hemodynamics,ventricular remodeling and adverse reactions in patients with heart failure complicated with ventricular arrhythmia.Methods Patients with heart failure complicated with ventricular arrhythmia from January 2019 to December 2022 were selected as research subjects.According to the different medication regimens,they were divided into the control group(n=45)and the test group(n=45).Patients in the control group were treated with metoprolol tartrate tablets and patients in the test group were treated with Shensong Yangxin capsule on the basis of the treatment in the control group.The therapeutic effects of heart failure and arrhythmia,the cardiac function indexes[left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)],ventricular remodeling indexes[matrix metalloproteinase-9(MMP-9)and left ventricular mass index(LVMI)],and the occurrence of adverse reactions were compared between two groups.Results The total effective rate of arrhythmia(97.78%vs.86.67%,P=0.049),the total effective rate of heart failure(95.56%vs.82.22%,P=0.044)in the test group were significantly higher than those in the control group.There was no significant difference in cardiac function indexes(LVEDD,LVESD)and ventricular remodeling indexes(MMP-9,LVMI)between two groups before treatment(P>0.05).After treatment,cardiac function indexes(LVEDD,LVESD)and ventricular remodeling indexes(MMP-9,LVMI)of the two groups were both significantly reduced(P<0.05).After treatment,the indexes of cardiac function(LVEDD,LVESD)and ventricular remodeling(MMP-9,LVMI)in the test group were significantly lower than those in the control group(P<0.05).Conclusion Shensong Yangxin capsule combined with metoprolol tartrate can effectively improve hemodynamics and ventricular remodeling in patients with heart failure complicated with ventricular arrhythmia.